Experiments for space and ground-based gravitational wave detectors often require a large dynamic range interferometric position readout of test masses with 1 pm/√Hz precision over long time scales. Heterodyne interferometer schemes that achieve such precisions are available, but they require complex optical set-ups, limiting their scalability for multiple channels. This article presents the first experimental results on deep frequency modulation interferometry, a new technique that combines sinusoidal laser frequency modulation in unequal arm length interferometers with a non-linear fit algorithm. We have tested the technique in a Michelson and a Mach-Zehnder Interferometer topology, respectively, demonstrated continuous phase tracking of a moving mirror and achieved a performance equivalent to a displacement sensitivity of 250 pm/Hz at 1 mHz between the phase measurements of two photodetectors monitoring the same optical signal. By performing time series fitting of the extracted interference signals, we measured that the linearity of the laser frequency modulation is on the order of 2% for the laser source used.
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http://dx.doi.org/10.1364/OE.24.001676 | DOI Listing |
Arterioscler Thromb Vasc Biol
January 2025
Department of Cardiology, The University of Texas MD Anderson Cancer Center, Houston. (B.C.-C., N.A.V.G., N.L.P., L.P.E., V.S.K.S., A.M.O., J.L., G.M., O.H., A.D., S.W.Y., C.A.I., K.C.O.M., S. Kotla, J.-i.A.).
Modulating immune function is a critical strategy in cancer and atherosclerosis treatments. For cancer, boosting or maintaining the immune system is crucial to prevent tumor growth. However, in vascular disease, mitigating immune responses can decrease inflammation and slow atherosclerosis progression.
View Article and Find Full Text PDFCureus
January 2025
Orthopedics, Nirmal Hospital, Jhansi, IND.
Introduction Excessive repetitive physical activity most often leads to acute musculoskeletal pain. The management of acute pain is one of the primary concerns. The nociceptive pain has both sensory and affective qualities, patterns, and intensity.
View Article and Find Full Text PDFPain Rep
February 2025
Department of Occupational Therapy, Graduate School of Rehabilitation Science, Osaka Metropolitan University, Osaka, Japan.
Introduction: Chronic low back pain (CLBP) is a global health issue, and its nonspecific causes make treatment challenging. Understanding the neural mechanisms of CLBP should contribute to developing effective therapies.
Objectives: To compare current source density (CSD) and functional connectivity (FC) extracted from resting electroencephalography (EEG) between patients with CLBP and healthy controls and to examine the correlations between EEG indices and symptoms.
J Pain Res
January 2025
NXTSTIM INC. Department of Pain Medicine, San Diego, CA, USA.
Transcutaneous Electrical Nerve Stimulation (TENS) and Electronic Muscle Stimulation (EMS) are non-invasive therapies widely used for pain relief and neuromuscular adaptation. However, the clinical research supporting the efficacy of TENS in chronic pain management is limited by significant methodological flaws, including small sample sizes and inconsistent reporting of stimulation parameters. TENS modulates pain perception through various techniques, targeting specific nerve fibers and pain pathways.
View Article and Find Full Text PDFNarra J
December 2024
Department of Pediatric, Dr. Zainoel Abidin Hospital, Banda Aceh, Indonesia.
Sepsis is a systemic infection that significantly causes morbidity and mortality among neonates, which is associated with immature immune response. Variations in the tumor necrosis factor-alpha gene () -308G/A may be linked to neonatal sepsis mortality by modulating interleukins (ILs) involved in the immune response cascade, such as IL-6. The aim of this study was to investigate the association between -308G/A gene variation and IL-6 level with mortality of neonatal sepsis.
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