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| http://dx.doi.org/10.4103/0366-6999.173554 | DOI Listing |
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Epileptiform discharges in the context of self-limited pediatric focal epilepsy (EDSelFEC) in pediatric hemispherotomy patients: Role of white matter abnormalities.
Epileptic Disord
December 2024
Center for Pediatric Neurology and Neurorehabilitation, Epilepsy Center for Children and Adolescents, Schoen Clinic Vogtareuth, Vogtareuth, Germany.
Objective: To investigate the frequency of epileptiform discharges associated with self-limited focal epilepsy (EDSelFEC) in children who have undergone a hemispherotomy and to evaluate whether patients with coexistence of EDSelFEC and structural hemispheric epilepsies differ from patients without coexistence of EDSelFEC and whether there are differences between the two groups with regard to preoperative management and postoperative outcome.
Methods: Data on 131 children who underwent a hemispherotomy between January 1999 and January 2015 were retrieved from the Epilepsy center's epilepsy surgery database. Children with EDSelFEC were compared with children without EDSelFEC with respect to epileptogenic hemispheric pathology, family history, age at epilepsy onset, timing of surgery, lesion laterality, preoperative cognitive function, response to sodium channel blocker antiepileptic medication, and surgical outcome.
Rasmussen Encephalitis: Clinical Features, Pathophysiology, and Management Strategies-A Comprehensive Literature Review.
Medicina (Kaunas)
November 2024
Neurology Department, Cooper University Hospital, Camden, NJ 08103, USA.
Rasmussen encephalitis (RE) is a rare and progressive form of chronic encephalitis that typically affects one hemisphere of the brain and primarily occurs in pediatric individuals. The current study aims to narratively review the literature about RE, including historical information, pathophysiology, and management of this condition. RE often occurs in individuals with normal development, and it is estimated that only a few new cases are identified each year in epilepsy centers.
View Article and Find Full Text PDFRituximab-responsive late-onset Rasmussen's encephalitis.
Seizure
December 2024
Ankara University, Faculty of Medicine, Department of Neurology, Ibn-i Sina Hospital, 06100, Ankara, Turkey.
Pregnancy and delivery after functional hemispherectomy for Rasmussen's encephalitis: a case report.
BMC Neurol
October 2024
Department of Obstetrics and Prenatal Medicine, University Hospital Bonn, Venusberg-Campus 1, 53127, Bonn, Germany.
Article Synopsis
- Rasmussen's encephalitis (RE) is a rare disorder causing severe seizures and brain atrophy in children, often requiring surgical intervention when treatments fail.
- A case study highlights a woman who had a left hemispherectomy at age seven and successfully went through two pregnancies, experiencing temporary worsening of her symptoms during each but returning to her baseline afterward.
- This situation underscores the lack of data on RE and pregnancy, emphasizing the need for careful monitoring and an interdisciplinary approach to ensure the health and safety of both mother and child during and after pregnancy.
Current practices in the diagnosis and treatment of Rasmussen syndrome: Results of an international survey.
Seizure
November 2024
Department of Epileptology, Krankenhaus Mara, Bethel Epilepsy Center, Medical School OWL, Bielefeld University, Maraweg 21, 33617, Bielefeld, Germany. Electronic address:
Article Synopsis
- - The study surveys medical providers about their current practices regarding the diagnosis and treatment of Rasmussen syndrome (RS), a condition that results in brain atrophy and various neurological issues.
- - Most providers conduct tests for autoimmune encephalitis, but there are significant differences in the use of genetic testing and biopsy across regions, especially between US and European doctors and those from elsewhere.
- - The findings reveal varying opinions on treatment priorities, particularly between surgical options and immunotherapy, indicating a need for further research and the development of consensus guidelines in RS management.
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