We present an unusual case of a retained crossbow bolt in the maxillofacial area of a 31-year-old man. While crossbow injuries are rare, this case is of interest because otolaryngologists are often faced with treating retained foreign objects after penetrating facial trauma. These cases are difficult to manage because of the complexity and variety of injuries that can occur during both the initial trauma and the removal. We focus on the management of the bolt's removal and provide a brief discussion of the relevant literature on crossbow injuries to the head and neck.
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View Article and Find Full Text PDFMechanism-guided engineering of a minimal biological particle for genome editing.
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Innovative Genomics Institute; University of California, Berkeley; Berkeley CA, USA.
The widespread application of genome editing to treat or even cure disease requires the delivery of genome editors into the nucleus of target cells. Enveloped Delivery Vehicles (EDVs) are engineered virally-derived particles capable of packaging and delivering CRISPR-Cas9 ribonucleoproteins (RNPs). However, the presence of lentiviral genome encapsulation and replication components in EDVs has obscured the underlying delivery mechanism and precluded particle optimization.
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Guizhou University of Traditional Chinese Medicine, Guiyang, 550025, China; The First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, China. Electronic address:
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Univ.-Augenklinik Heidelberg, Medizinische Fakultät Heidelberg der Universität Heidelberg, Im Neuenheimer Feld 400, 69120, Heidelberg, Deutschland.
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Department of Neurological Surgery, Indiana University School of Medicine and Goodman Campbell Brain and Spine, Indianapolis, Indiana, USA.
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