AI Article Synopsis
- The study investigated how central ghrelin (GHRL) affects liver lipid metabolism in rainbow trout, especially when combined with oleate treatment.
- GHRL was shown to increase lipogenesis while reducing fatty acid oxidation, countering the effects of oleate that decreased lipogenesis and enhanced oxidative capacity.
- The findings highlight the hypothalamus's role in regulating energy metabolism in fish through nutrient sensing mechanisms influenced by GHRL.
Article Abstract
We aimed to elucidate in rainbow trout (Oncorhynchus mykiss) the effects of central ghrelin (GHRL) treatment on the regulation of liver lipid metabolism, and the possible modulatory effect of central GHRL treatment on the simultaneous effects of raised levels of oleate. Thus, we injected intracerebroventricularly (ICV) rainbow trout GHRL in the presence or absence of oleate and evaluated in liver variables related to lipid metabolism. Oleate treatment elicited in liver of rainbow trout decreased lipogenesis and increased oxidative capacity in agreement with previous studies. Moreover, as demonstrated for the first time in fish in the present study, GHRL also acts centrally modulating lipid metabolism in liver, resulting in increased potential for lipogenesis and decreased potential for fatty acid oxidation, i.e. the converse effects to those elicited by central oleate treatment. The simultaneous treatment of GHRL and oleate confirmed these counteractive effects. Thus, the nutrient sensing mechanisms present in hypothalamus, particularly those involved in sensing of fatty acid, are involved in the control of liver energy metabolism in fish, and this control is modulated by the central action of GHRL. These results give support to the notion of hypothalamus as an integrative place for the regulation of peripheral energy metabolism in fish.
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| http://dx.doi.org/10.1016/j.ygcen.2016.01.016 | DOI Listing |
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