AI Article Synopsis
- In September 2013, two cholera cases were identified in Mexico City, confirmed as Vibrio cholerae serogroup O1, serotype Ogawa, biotype El Tor, with strains differing from previous cases in Mexico.
- A subsequent outbreak occurred in Hidalgo, with four additional cases reported, leading to a larger cholera outbreak in the La Huasteca region.
- Genomic analysis of the isolates revealed similarities to the strain associated with the 2010 Haiti epidemic, confirming the presence of important pathogenicity genes and elements.
Article Abstract
The first week of September 2013, the National Epidemiological Surveillance System identified two cases of cholera in Mexico City. The cultures of both samples were confirmed as Vibrio cholerae serogroup O1, serotype Ogawa, biotype El Tor. Initial analyses by PFGE and by PCR-amplification of the virulence genes, suggested that both strains were similar, but different from those previously reported in Mexico. The following week, four more cases were identified in a community in the state of Hidalgo, located 121 km northeast of Mexico City. Thereafter a cholera outbreak started in the region of La Huasteca. Genomic analyses of the four strains obtained in this study confirmed the presence of Pathogenicity Islands VPI-1 and -2, VSP-1 and -2, and of the integrative element SXT. The genomic structure of the 4 isolates was similar to that of V. cholerae strain 2010 EL-1786, identified during the epidemic in Haiti in 2010.
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| http://dx.doi.org/10.1016/j.micinf.2016.01.004 | DOI Listing |
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