AI Article Synopsis
- A study investigated the changes in brain thickness and cognitive ability over time in 19 Alzheimer's disease (AD) patients, 10 patients with behavioral variant frontotemporal dementia (bvFTD), and 34 control subjects over an average period of 2.1 years.
- Results showed that both AD and bvFTD patients experienced faster cognitive decline and more rapid cortical thinning relative to controls, with AD patients experiencing the most significant overall loss across the brain, particularly in the posterior regions.
- In comparing the two diseases, AD patients had larger declines in brain thickness in the insula and temporal/parietal regions, while bvFTD showed targeted thinning primarily in the frontal and anterior temporal areas, with cognitive decline paralleling the observed
Article Abstract
We examined patterns of cortical thickness loss and cognitive decline over time in 19 patients with Alzheimer's disease (AD), 10 with behavioral variant frontotemporal dementia (bvFTD), and 34 controls with a mean interval of 2.1 ± 0.4 years. We measured vertexwise and regional cortical thickness changes of 6 lobar regions of interest between groups with the longitudinal FreeSurfer pipeline. Compared with controls, AD and bvFTD had a steeper rate of cognitive decline and showed faster cortical thinning per year. Decrease of thickness over time was highest in AD and generalized throughout the whole brain, most pronounced posteriorly, whereas bvFTD patients had a more selective loss in frontal cortex and in anterior parts of the temporal lobes. In a direct comparison, AD patients showed faster cortical thinning in the insula, temporal, and parietal regions, whereas bvFTD patients only showed faster cortical thinning in the orbitofrontal gyrus. Decline of cognitive performances was in line with cortical thinning and deteriorated the most in AD patients.
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| http://dx.doi.org/10.1016/j.neurobiolaging.2015.10.020 | DOI Listing |
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