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This study explores the hypothesis about the possible involvement of the cyclooxygenase pathway in the effects of interleukin-1beta (IL-1β) on the breathing pattern and Heuring-Breuer respiratory reflexes. Respiratory frequency (fR), tidal volume (VT) and esophageal pressure were recorded in 29 adult male Wistar rats anaesthetized with urethane. Heuring-Breuer reflexes were tested by airway occlusion at achieving functional residual capacity (inspiratory-inhibitory reflex), and at the height of inspiration (expiratory-promoting reflex). It had been shown that an elevation of IL-1β in the systemic circulation causes an increase in VT, fR, lung ventilation and strengthens respiratory reflexes. These respiratory effects had not been shown if IL-1β administered after intraperitoneal injection of diclofenac, which had not any significant respiratory effects by itself. Because diclofenac is a non-specific antagonist of cyclooxygenases, it had been concluded that the prostaglandins mediate respiratory effects of IL-1β in point of fact.
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