Piperidine is the most significant scaffold which reveals therapeutic potential because of its conformationally flexible nature. During the course of present investigations synthetic quaternary salts of alkyl piperidine with various phenacyl bromides were explored for their possible analgesic activity. Compounds I analogs (1a-1f) and compound II analogs (IIa-IIf) showed varying degree of analgesic activity when compared with pethidine as standard and its duration by tail immersion method.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
analgesic activity
12
alkyl piperidine
8
activity alkyl
4
piperidine derivatives
4
derivatives piperidine
4
piperidine scaffold
4
scaffold reveals
4
reveals therapeutic
4
therapeutic potential
4
potential conformationally
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!