AI Article Synopsis
- Eukaryotic chromatin is a negatively charged polymer made of DNA, histones, and proteins, which allows for dynamic structural changes critical for genome functions like gene expression.
- These changes can influence how accessible DNA is, impacting processes like DNA replication, repair, and recombination.
- Recent evidence suggests that chromatin has a liquid-like structure, particularly in its 10-nm fiber form, which enhances its ability to scan and target genomic DNA effectively.
Article Abstract
Eukaryotic chromatin is a negatively charged long polymer composed of genomic DNA, histones, and various proteins. The charged property causes the chromatin structure to be dynamically changed. These dynamic changes are critical for genome functions such as gene expression because they directly govern the degree of DNA accessibility. Although the chromatin structure is not yet fully understood, currently increasing evidence suggests that chromatin has a dynamic liquid-like structure based on the 10-nm fiber but not the 30-nm fiber. This liquid-like property can drive the process of 'scanning and targeting genomic DNA,' which contributes to various genome functions including gene expression and DNA replication, repair, and recombination. Here, we discuss the liquid-like behavior of chromatin and its physical and biological relevance.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.gde.2015.11.006 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!