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Computational analysis of long QT syndrome type 2 and the therapeutic effects of KCNQ1 antibodies.
Digit Health
October 2024
College of Computer Science and Technology, Ocean University of China, Qingdao, China.
Objective: Long QT interval syndrome (LQTS) is a highly dangerous cardiac disease that can lead to sudden cardiac death; however, its underlying mechanism remains largely unknown. This study is conceived to investigate the impact of two general genotypes of LQTS type 2, and also the therapeutic effects of an emerging immunology-based treatment named KCNQ1 antibody.
Methods: A multiscale virtual heart is developed, which contains multiple biological levels ranging from ion channels to a three-dimensional cardiac structure with realistic geometry.
Leukotriene B4 is elevated in diabetes and promotes ventricular arrhythmogenesis in guinea pig.
J Cell Physiol
October 2024
Nora Eccles Harrison Cardiovascular Research and Training Institute (CVRTI), University of Utah School of Medicine, Salt Lake City, Utah, USA.
Article Synopsis
- Diabetes patients have a higher risk (~50%) of sudden cardiac death primarily due to ventricular arrhythmias, with the proinflammatory lipid mediator leukotriene B4 (LTB4) playing a significant role.
- In studies using guinea pig hearts, it was found that elevated LTB4 in diabetic models leads to harmful heart rhythms and decreases critical potassium current, affecting heart function.
- The research indicates that targeting LTB4 receptors could be a promising therapeutic strategy to improve heart health and reduce the risk of sudden cardiac death in diabetes patients.
The Society of Thoracic Surgeons Preoperative Beta Blocker Working Group Interim Report.
Ann Thorac Surg
August 2024
Department of Anesthesiology, Vanderbilt University Medical Center, Nashville, Tennessee.
Background: Atrial fibrillation (AF) occurs commonly after cardiac surgery and is associated with multiple adverse outcomes. Older randomized trials suggested that perioperative β- blockade reduced postoperative AF, and The Society of Thoracic Surgeons (STS) coronary artery bypass grafting (CABG) composite measure includes β-blocker administration preoperatively within 24 hours of surgery and at discharge. However, some more recent studies suggest preoperative β-blockade has limited value and question its continuation as an STS quality measure.
View Article and Find Full Text PDFObesity Arrhythmias: Role of IL-6 Trans-Signaling.
Int J Mol Sci
August 2024
Nora Eccles Harrison Cardiovascular Research and Training Institute (CVRTI), University of Utah School of Medicine, Salt Lake City, UT 84112, USA.
Article Synopsis
- - Obesity is a major and growing global health issue, affecting over 600 million adults and projected to double by 2030, with significant implications for heart health, particularly concerning arrhythmias in those with long QT syndrome.
- - The excess fat in obese individuals triggers chronic inflammation through the release of IL-6, a cytokine that increases the risk of severe heart diseases and arrhythmias by altering heart function.
- - Despite promising results from the IL-6 inhibitor olamkicept in treating other inflammatory conditions, the specific link between IL-6 trans-signaling and heart rhythm disturbances in obesity has yet to be fully investigated, highlighting a crucial area for future research.
Wide QRS tachycardia in a patient with atrial fibrillation: a case report and approach to diagnosis.
Eur Heart J Case Rep
August 2024
Division of Cardiovascular Diseases, Heart Rhythm Services, St. Rita's Medical Center, Lima, OH 45801, USA.
Background: Wide QRS complex (QRS) tachycardia in patients with atrial fibrillation (AF) or atrial flutter treated with antiarrhythmic drugs can occur for a variety of reasons and needs careful evaluation for appropriate management of the patient.
Case Summary: We report a case of wide QRS complex tachycardia in a patient with AF treated with Flecainide who received multiple external cardioversion attempts for a presumed diagnosis of ventricular tachycardia. Intravenous Diltiazem and an oral beta-blocker led to the resolution of wide QRS complex tachycardia.
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