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Exploring physiological responses through electrodermal activity (EDA) for evaluating the impact of universal design features in a hotel environment.
Disabil Rehabil Assist Technol
January 2025
Industrial and Systems Engineering, University at Buffalo, Buffalo, NY, USA.
The aim of this study was to explore the feasibility of using electrodermal activity (EDA) to detect changes in physiological arousal linked to perceptions of accommodations, focusing on universal design (UD) features. In environments like hotels, designers must consider wellness, social integration, and cultural appropriateness to effectively implement UD. Challenges exist with implementing and evaluating UD to accommodate diverse user needs due to conflicting definitions and application issues.
View Article and Find Full Text PDFCommentary on: γ-enolase (ENO2) is methylated at the Nτ position of His-190 among enolase isozymes.
J Biochem
December 2024
Department of Biomedical Science, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-dori, Mizuho-ku, Nagoya, Aichi 467-8603, Japan.
Post-translational modifications play crucial roles in regulating protein function. Protein methylation, occurring at lysine, arginine, and histidine, has gained attention, particularly for histone methylation. However, the mechanism and significance of protein methylation at histidine remains poorly understood.
View Article and Find Full Text PDFHealth and Social Care Inequalities During the First Wave of COVID-19 in Italy; Comment on "Experiences and Implications of the First Wave of the COVID-19 Emergency in Italy: A Social Science Perspective".
Int J Health Policy Manag
November 2024
Institute of Research on Population and Social Policies, Rome, Italy.
The impact of COVID-19 on the Italian population is well-known and has been deeply analysed under the clinical and epidemiological perspectives where the majority of the studies focused on the beginning of the first wave (March-May 2020). However, there is a need for analysing this complex phenomenon integrating the clinical side with the economic and social lens to better understand implications of a pandemic for populations. In their paper Masino and Enria focused the attention on four specific perspectives: health system reaction to the pandemic, inequalities in the work world, social care from the elderly point of view and the government communication challenges.
View Article and Find Full Text PDFEvaluating diclofenac's risks in COVID-19: strategies for mitigating adverse outcomes.
Inflammopharmacology
November 2024
School of Pharmacy, International Medical University, Kuala Lumpur, Malaysia.
The use of nonsteroidal anti-inflammatory drugs (NSAIDs), particularly diclofenac, during the COVID-19 pandemic has raised concerns due to its potential to worsen disease progression. This commentary evaluates key risks associated with diclofenac and highlights the critical role of pharmacists in mitigating adverse outcomes through careful medication management and patient education. Diclofenac poses unique risks due to its ability to generate reactive oxygen species (ROS), leading to oxidative stress and mitochondrial dysfunction.
View Article and Find Full Text PDFPharmacotherapy for patients with calcium oxalate stones and abnormal urine chemistry: A systematic review and meta-analysis for the Japanese Clinical Practice Guidelines for the Management of Urinary Stones, Third Edition.
Int J Urol
January 2025
Department of Urology, Wakayama Medical University, Wakayama, Japan.
We performed a systematic review and meta-analysis to evaluate the benefits and harms of pharmacotherapies for patients with calcium oxalate stones and abnormal urine chemistry. This article is a modified and detailed version of the commentary on Clinical Question 10 described in the Japanese Clinical Practice Guidelines for the Management of Urinary Stones, Third Edition. PubMed and Ichushi Web were searched through August 2020 for articles on pharmacotherapies for calcium oxalate stones (thiazides, citrate preparations, uric acid production inhibitors, and magnesium preparations).
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