AI Article Synopsis
- Primary bone NK/T cell lymphoma is an uncommon type of cancer, as illustrated by a case involving a 52-year-old man who developed NK leukemia after initially presenting with the lymphoma.
- The patient experienced low-grade fever for four months, and imaging revealed enlargement of the liver and spleen without swollen lymph nodes.
- Diagnosis required a bone sample, showing specific markers on the neoplastic cells, which helps differentiate it from other types of lymphoma or leukemia that can also affect bones.
Article Abstract
Primary bone NK/T cell lymphoma is very rare. We report a case of 52-year-old man of primary bone NK/T cell lymphoma and then progressed to NK leukemia. The patient had low-grade fever for 4-month, and Ultrasonic B revealed a diffuse hepatosplenomegaly without lymphadenopathy. PET scanning showed increased FDG uptake in many bones of the whole body. The diagnosis was established by bone specimen. These neoplastic cells demonstrated a typical immunophenotype of CD56, CD3, CD2 and MPO positive, and CD5, CD20, CD30, PAX-5, CD4 and CD8 negative. Primary bone ENKTL is very rare; it should be made with the combination of clinical feature, PET-CT image, and pathological characteristics, and should be distinguished from other lymphomas or leukemia involved in bone.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4713599 | PMC |
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