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Synergistic Effects of Anti-echinococcosis Drug Candidates Combined With Atovaquone in Culture Assays and Mice With Primary Infections of Echinococcus multilocularis.
Cureus
November 2024
Department of Pediatrics, Teikyo University School of Medicine, Tokyo, JPN.
Background Alveolar echinococcosis (AE) is a fatal zoonotic disease distributed mainly in the Northern Hemisphere. At present, its curative treatment relies on surgery, and the development of effective drugs is needed. We previously demonstrated the anti-echinococcal effect of atovaquone (ATV) as a mitochondrial complex III inhibitor in both in vitro and in vivo experiments.
View Article and Find Full Text PDFCoexistence of kidney and lung hydatid cyst in a child: A case report.
Respir Med Case Rep
November 2024
Tehran University of Medical Sciences, Tehran, Iran.
Hydatid cyst (HC) is a zoonotic disease that often affects regions where animal husbandry is common and preventive measures are not taken. This disease mostly affects the liver and the lungs. Involvement of other organs, such as the kidney, musculoskeletal system, and intracranial structures, is rare.
View Article and Find Full Text PDFThe protective effect of the vagus nerve-α7nAChR-IL-22 pathway on acute liver injury.
Cytokine
December 2024
Department of Hepatobiliary & Hydatid Disease, Digestive & Vascular Surgery Center, the First Affiliated Hospital of Xinjiang Medical University, Urumqi, China; State Key Laboratory of Pathogenesis, Prevention, Treatment of High Incidence Diseases in Central Asia, Xinjiang Medical University, Urumqi, China. Electronic address:
Background: Acute liver injury is a common pathological feature of various clinical diseases, and prolonged liver damage can lead to fibrosis and even liver failure. Studies have reported that the vagus nerve can repair liver injury through the regulation of the cholinergic anti-inflammatory pathway. However, there is limited research on the regulation of interleukin-22 and its role in liver injury.
View Article and Find Full Text PDFHydatid Disease With Psoas and Gluteal Muscle Involvement Causing Cauda Equina Compression: A Case Report.
Cureus
November 2024
General Surgery, Tangier University Hospital, Abdelmalek Essaâdi University, Tangier, MAR.
Hydatid disease is a zoonotic infection caused by the tapeworm, primarily affecting the liver and lungs, and rarely involving muscle tissue. Humans are infected by ingesting eggs from contaminated food or water. Patients may present with painless, slow-growing masses, sometimes associated with nerve or vessel compression, especially in cases of muscle involvement.
View Article and Find Full Text PDFEchinococcosis: An Uncommon Cause of Thoracic Pain.
Cureus
November 2024
Internal Medicine, Centro Hospitalar Universitário de Lisboa Central, Lisbon, PRT.
Echinococcosis is caused by larvae, the metacestode stage of the tapeworm , and poses a public health issue in many developing countries. It generally affects a single organ, most commonly the liver or lungs, and rarely involves multiple organs. We present the case of a 24-year-old Indian man living in Portugal, who was admitted to the Emergency Department with left-sided thoracic pain radiating to the back.
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