AI Article Synopsis
- Age-related neurodegenerative diseases like Alzheimer’s are influenced by genetics, environment, and diet, with Omega-3 phospholipids potentially lowering Alzheimer’s risk.
- Researchers studied how the Alzheimer peptide Aβ-(1-42) interacts with lipid bilayers, particularly those enriched with Omega-3, using techniques like Circular Dichroism (CD) and Electron Spin Resonance (ESR).
- The presence of specific Omega-3 lipids enhances the interaction between Aβ-(1-42) and lipid membranes, indicating that the lipid composition could be key to understanding and treating Alzheimer's disease.
Article Abstract
Many age-related neurodegenerative diseases, including Alzheimer Disease (AD), are elicited by an interplay of genetic, environmental, and dietary factors. Food rich in Omega-3 phospholipids seems to reduce the AD incidence. To investigate the molecular basis of this beneficial effect, we have investigated by CD and ESR studies the interaction between the Alzheimer peptide Aβ-(1-42) and biomimetic lipid bilayers. The inclusion of 1,2-didocosahexaenoyl-sn-glycero-3-phosphocholine does not change significantly the bilayers organization, but favors its Aβ-(1-42) interaction. The Omega-3 lipid amount modulates the effect intensity, suggesting a peptide selectivity for membranes containing polyunsatured fatty acids (PUFA) and providing hints for the mechanism and therapy of AD.
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| http://dx.doi.org/10.1002/1873-3468.12082 | DOI Listing |
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