AI Article Synopsis
- The study evaluates a rapid diagnostic test for HIV (Alere HIV Combo) that uses a fourth-generation immunochromatographic method.
- The test demonstrated a 100% sensitivity and 99.3% specificity, matching the accuracy of traditional testing methods (CLIA).
- It effectively detects HIV-1p24 antigen in various sample types (whole blood, plasma, serum), making it suitable for quick use in general healthcare settings.
Article Abstract
Extremely early diagnosis of human immunodeficiency virus (HIV) infection has been considered highly important for its treatment. We conducted a performance assessment of a newly developed rapid diagnostic reagent for HIV by using a fourth-generation immunochromatographic assay (Alere HIV Combo). We used whole-blood, plasma, and serum samples obtained from 250 Japanese adults who visited the Kawasaki Medical School Hospital and underwent HIV screening tests. We also used 12 types of commercial HIV-1 sero- conversion panels and World Health Organization standard antigens. This method, which has a detection sensitivity of 100% and a specificity of 99.3%, was as accurate as the chemiluminescent immunoassay (CLIA) method. In a sensitivity test using seroconversion panels in the early phase of infection, the mean duration until positive conversion was 19.3 days. With this method having a high detection sensitivity for HIV-1p24 antigen, the results from whole-blood samples were the same as those from plasma and serum samples. Therefore, it can be considered as a useful rapid measurement method for general practice.
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| http://dx.doi.org/10.11150/kansenshogakuzasshi.89.733 | DOI Listing |
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