Baculoviruses are widely used both as protein expression vectors and as insect pest control agents. This section provides an overview of the baculovirus life cycle and use of baculoviruses as insecticidal agents. This chapter includes discussion of the pros and cons for use of baculoviruses as insecticides, and progress made in genetic enhancement of baculoviruses for improved insecticidal efficacy. These viruses are used extensively for control of insect pests in a diverse range of agricultural and forest habitats.
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Development of a novel sandwich immunoassay based on targeting recombinant Francisella outer membrane protein A for the diagnosis of tularemia.
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Biotherapeutics Translational Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Republic of Korea.
Article Synopsis
- * Researchers produced FopA antigen using a baculovirus system and generated specific antibodies by immunizing mice, then screened these using hybridoma and phage display technologies.
- * Two monoclonal antibodies (6B12 and 3C1) were successfully developed, leading to a sensitive sandwich ELISA for tularemia diagnosis with low detection limits, providing a more effective alternative to traditional tests.
Introduction: The COVID-19 pandemic caused by SARS-CoV-2 has created serious health problems worldwide. The most effective way to prevent the occurrence of new epidemic outbreaks is vaccination. One of the modern and effective approaches to vaccine development is the use of virus-like particles (VLPs).
View Article and Find Full Text PDFis a virus resistance gene in .
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Integrative Science Center of Germplasm Creation in Western China (Chongqing) Science City, Biological Science Research Center, Southwest University, Chongqing, China.
Introduction: Signal peptide peptidase () is an intramembrane protease involved in a variety of biological processes, it participates in the processing of signal peptides after the release of the nascent protein to regulate the endoplasmic reticulum associated degradation (ERAD) pathway, binds misfolded membrane proteins, and aids in their clearance process. Additionally, it regulates normal immune surveillance and assists in the processing of viral proteins. Although is essential for many viral infections, its role in silkworms remains unclear.
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Guangdong Provincial Key Laboratory of Agro-animal Genomics and Molecular Breeding, College of Animal Science, South China Agricultural University, Guangzhou, China.
Introduction: The brain is considered as an immune-privileged organ, yet innate immune reactions can occur in the central nervous system of vertebrates and invertebrates. Silkworm (Bombyx mori) is an economically important insect and a lepidopteran model species. The diversity of cell types in the silkworm brain, and how these cell subsets produce an immune response to virus infection, remains largely unknown.
View Article and Find Full Text PDFEvaluation of recombinant baculovirus clearance during rAAV production in Sf9 cells using a newly developed fluorescent-TCID assay.
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Avirmax CMC Inc., Hayward, CA, United States.
Introduction: Recombinant adeno-associated virus (rAAV) vectors provide a safe and efficient means for gene delivery, although its large-scale production remains challenging. Featuring high manufacturing speed, flexible product design, and inherent safety and scalability, the baculovirus/Sf9 cell system offers a practical solution to the production of rAAV vectors in large quantities and high purity. Nonetheless, removal and inactivation of recombinant baculoviruses during downstream purification of rAAV vectors remain critical prior to clinical application.
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