AI Article Synopsis
- The study aimed to identify changes in inflammatory mediator concentrations in plasma and urine after traumatic spinal cord injury (SCI) and prior to the onset of a pressure ulcer.
- A retrospective analysis involved matched individuals with and without pressure ulcers, using plasma and urine samples collected from SCI patients shortly after injury.
- Results showed increased levels of a specific chemokine in plasma and decreased levels of a cytokine in urine, suggesting that these inflammatory markers could help identify individuals at risk for developing pressure ulcers following SCI.
Article Abstract
Objective: To identify changes in concentrations of inflammatory mediators in plasma and urine after traumatic spinal cord injury (SCI) and before the occurrence of a first pressure ulcer.
Design: Retrospective; secondary analysis of existing data.
Setting: Acute hospitalization and inpatient rehabilitation sites at a university medical center.
Participants: Individuals with a pressure ulcer and plasma samples (n=17) and individuals with a pressure ulcer and urine samples (n=15) were matched by age and plasma/urine sample days to individuals with SCI and no pressure ulcer (N=35).
Interventions: Not applicable.
Main Outcome Measures: Plasma and urine samples were assayed in patients with SCI, capturing samples within 4 days after the SCI to a week before the formation of the first pressure ulcer. The Wilcoxon signed-rank test was performed to identify changes in the inflammatory mediators between the 2 time points.
Results: An increase in concentration of the chemokine interferon-γ-induced protein of 10kd/CXCL10 in plasma (P<.01) and a decrease in concentration of the cytokine interferon-α in urine (P=.01) were observed before occurrence of a first pressure ulcer (∼4d) compared with matched controls.
Conclusions: Altered levels of inflammatory mediators in plasma and urine may be associated with pressure ulcer development after traumatic SCI. These inflammatory mediators should be explored as possible biomarkers for identifying individuals at risk for pressure ulcer formation.
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| http://dx.doi.org/10.1016/j.apmr.2016.01.003 | DOI Listing |
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