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Air Pollution and Myocardial Infarction-A New Smoker's Paradox?
J Clin Med
December 2024
Division of Cardiology, Department of Internal Medicine, Medical University of Graz, 8036 Graz, Austria.
Ambient air pollution is a significant public health concern, known to affect cardiovascular health adversely. Research has identified both long-term and short-term cardiovascular risks associated with various air pollutants, including those linked to acute coronary syndromes. However, the observed effects are rather small, with most data sourced from highly polluted regions.
View Article and Find Full Text PDFMathematical modeling suggests heterogeneous replication of Mycobacterium tuberculosis in rabbits.
PLoS Comput Biol
November 2024
Public Health Research Institute, The State University of New Jersey, Newark, New Jersey, United States of America.
Tuberculosis (TB), the disease caused by Mycobacterium tuberculosis (Mtb), remains a major health problem with 10.6 million cases of the disease and 1.6 million deaths in 2021.
View Article and Find Full Text PDFThe Aryl Hydrocarbon Receptor Controls IFNγ-Induced Immune Checkpoints PD-L1 and IDO via the JAK/STAT Pathway in Lung Adenocarcinoma.
bioRxiv
August 2024
Department of Environmental Health, Boston University School of Public Health.
While immunotherapy has shown efficacy in lung adenocarcinoma (LUAD) patients, many respond only partially or not at all. One limitation in improving outcomes is the lack of a complete understanding of immune checkpoint regulation. Here, we investigated a possible link between an environmental chemical receptor implicated in lung cancer and immune regulation, (the aryl hydrocarbon receptor/AhR), a known but counterintuitive mediator of immunosuppression (IFNγ), and regulation of two immune checkpoints (PD-L1 and IDO).
View Article and Find Full Text PDFRadiotherapy toxicity prediction using knowledge-constrained generalized linear model.
IISE Trans Healthc Syst Eng
July 2023
H. Milton Stewart School of Industrial and Systems Engineering, Georgia Institute of Technology, Atlanta, GA, USA.
Radiation therapy (RT) is a frontline approach to treating cancer. While the target of radiation dose delivery is the tumor, there is an inevitable spill of dose to nearby normal organs causing complications. This phenomenon is known as radiotherapy toxicity.
View Article and Find Full Text PDFEchocardiographic diagnosis and clinical implications of wide-open tricuspid regurgitation for evaluating right ventricular dysfunction in the emergency department.
Am J Emerg Med
June 2024
Department of Emergency Medicine, Rutgers New Jersey Medical School, Newark, NJ 07103, USA. Electronic address:
The tricuspid regurgitation pressure gradient (TRPG) reflects the difference in pressure between the right ventricle and right atrium (ΔP). Its estimation by echocardiography correlates well with that obtained using right-heart catheterization. An elevated TRPG is an important marker for identifying right ventricular dysfunction in both the acute and chronic settings.
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