With its headwaters in the water towers of the western Cordillera of North America, the Fraser River is one of the continent's mightiest rivers by annual flows, supplies vital freshwater resources to populous downstream locations, and sustains the world's largest stocks of sockeye salmon along with four other salmon species. Here we show the Variable Infiltration Capacity (VIC) model's ability to reproduce accurately observed trends in daily streamflow for the Fraser River's main stem and six of its major tributaries over 1949-2006 when air temperatures rose by 1.4 °C while annual precipitation amounts remained stable. Rapidly declining mountain snowpacks and earlier melt onsets result in a 10-day advance of the Fraser River's spring freshet with subsequent reductions in summer flows when up-river salmon migrations occur. Identification of the sub-basins driving the Fraser River's most significant changes provides a measure of seasonal predictability of future floods or droughts in a changing climate.
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http://dx.doi.org/10.1038/srep19299 | DOI Listing |
JMIR Infodemiology
December 2024
Department of Computer Science, University of Saskatchewan, Saskatoon, SK, Canada.
Background: Understanding advocacy strategies is essential to improving dementia awareness, reducing stigma, supporting cognitive health promotion, and influencing policy to support people living with dementia. However, there is a dearth of evidence-based research on advocacy strategies used to support dementia awareness.
Objective: This study aimed to use posts from X (formerly known as Twitter) to understand dementia advocacy strategies during World Alzheimer's Awareness Month in September 2022.
Ecology
December 2024
Wildlife Research and Monitoring Section, Ministry of Natural Resources and Forestry, Peterborough, Ontario, Canada.
Animals within social groups respond to costs and benefits of sociality by adjusting the proportion of time they spend in close proximity to other individuals in the group (cohesion). Variation in cohesion between individuals, in turn, shapes important group-level processes such as subgroup formation and fission-fusion dynamics. Although critical to animal sociality, a comprehensive understanding of the factors influencing cohesion remains a gap in our knowledge of cooperative behavior in animals.
View Article and Find Full Text PDFAAPS J
December 2024
Regeneron Pharmaceuticals, Bioanalytical Sciences, 777 Old Saw Mill River Road, Tarrytown, New York, 10591, USA.
The ADA testing strategy for protein therapeutics was established almost two decades ago when assay methodologies were rudimentary, and serious immunogenicity-related safety issues had recently been observed with some biotherapeutics. The current testing paradigm employs multiple tiers and stringent cut points to minimize false negatives, reflecting a conservative stance towards ADA analysis. The development of highly sensitive ADA assay platforms and technologies such as humanized or fully human monoclonal antibody (mAb) drugs has put the traditional, resource-intensive 3-tiered testing approach under scrutiny.
View Article and Find Full Text PDFJ Forensic Sci
December 2024
Centre for Forensic Research, School of Criminology, Simon Fraser University, Burnaby, British Columbia, Canada.
Early detection of submerged bodies is essential to increase the possibility of recovery. Different water bodies present different challenges, particularly rivers and the ocean, where chances of detection are vastly reduced. Modern recreational fish finders incorporate multiple sonar technologies, including Sidescan sonar, at high-frequency resolutions, similar to commercial units.
View Article and Find Full Text PDFNucleic Acids Res
December 2024
Bioinformatics Group, Wageningen University & Research, Droevendaalsesteeg 1, 6708 PB Wageningen, The Netherlands.
Specialized or secondary metabolites are small molecules of biological origin, often showing potent biological activities with applications in agriculture, engineering and medicine. Usually, the biosynthesis of these natural products is governed by sets of co-regulated and physically clustered genes known as biosynthetic gene clusters (BGCs). To share information about BGCs in a standardized and machine-readable way, the Minimum Information about a Biosynthetic Gene cluster (MIBiG) data standard and repository was initiated in 2015.
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