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| http://dx.doi.org/10.1073/pnas.1516347113 | DOI Listing |
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Phosphorylation of Bok at Ser-8 blocks its ability to suppress IPR-mediated calcium mobilization.
Cell Commun Signal
January 2025
Department of Pharmacology, SUNY Upstate Medical University, Syracuse, NY, 13210, USA.
Background: Bok is a poorly characterized Bcl-2 protein family member with roles yet to be clearly defined. It is clear, however, that Bok binds strongly to inositol 1,4,5-trisphosphate (IP) receptors (IPRs), which govern the mobilization of Ca from the endoplasmic reticulum, a signaling pathway required for many cellular processes. Also known is that Bok has a highly conserved phosphorylation site for cAMP-dependent protein kinase at serine-8 (Ser-8).
View Article and Find Full Text PDFSerendipity in Science: 50+ Years of Designed, and Sometimes Lucky, Science.
Int J Sports Physiol Perform
December 2024
University of Leon, Leon, Spain.
Normal science is about assessing what is already known about a topic, about what needs to be known, and careful methods to collect the data required to answer the scientific question. It is the mainstay of scientific progress. But sometimes, luck or chance (eg, serendipity) plays a significant role in scientific process.
View Article and Find Full Text PDFHypoxia-inducible factor-1α-deficient adipose-tissue macrophages produce the heat to mediate lipolysis of white adipose tissue through uncoupling protein-1.
Lab Anim Res
October 2024
College of Veterinary Medicine, Seoul National University, Seoul, 08826, Korea.
Background: Uncoupling protein 1 (UCP1) is a proton uncoupler located across the mitochondrial membrane generally involved in thermogenesis of brown adipose tissues. Although UCP1 is known to be strongly expressed in brown adipocytes, recent evidence suggest that white adipocytes can also express UCP1 under certain circumstances such as cold- or β-adrenergic receptor-stimulation, allowing them to acquire brown adipocyte-like features thereby becoming 'beige' adipocytes.
Results: In this study, we report that UCP1 can be expressed in adipose-tissue macrophages (ATM) lacking functional hypoxia-inducible factor-1 (HIF-1) and this does not require cold- nor β-adrenergic receptor activation.
Characteristics of secondary aerosol formation during shortened multiday reaction experiments in a smog chamber: Effects of relative humidity and ammonia.
Sci Total Environ
December 2024
Center for Sustainable Environment Research, Korea Institute of Science and Technology, Hwarangro 14-gil 5, Seongbuk-gu, Seoul 02792, Republic of Korea; Graduate School of Energy and Environment (KU-KIST GREEN SCHOOL), Korea University, 145 Anam-ro, Seongbuk-gu, Seoul 02841, Republic of Korea. Electronic address:
Article Synopsis
- Researchers conducted multiday experiments using the KIST chamber to study how ammonia (NH) and relative humidity (RH) influence the creation of secondary organic aerosols (SOA) from toluene and inorganic gases, revealing that humid conditions lead to significantly higher SOA formation.
- The experiments showed that at 80% relative humidity, SOA production was 1.1 times greater in multiday initial injection tests compared to single-day tests and 1.6 times greater than in multiday cyclic injection tests, indicating that nighttime conditions contribute to increased SOA without needing additional emissions.
- Findings suggest that reducing ammonia levels could help lower SOA and other particulate matter pollution, with greater humidity accelerating SOA formation, which is crucial
Magnetic Detection of Neural Activity by Nanocoil Transducers.
Nano Lett
October 2024
Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, Wisconsin 53706, United States.
Electrophysiological recordings from brain cells are performed routinely using implanted electrodes, but they traditionally require a wired connection to the outside of the brain. A completely passive, wireless device that does not require on-board power for active transmission but that still facilitates remote detection could open the door for mass-scale direct recording of action potentials and transform the way we acquire brain signals. We present a nanofabricated coil that forms a neuroelectromagnetic junction, yielding a highly enhanced magnetic field transduction of electrophysiology.
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