Comrey and Harman & Jones have proposed different methods of factor analyzing a correlation matrix using on!y the off-diagonal elements. The purpose of such procedures is to avoid using the diagonal communality elements of the matrix theft are generally unknown and must be estimated. This study was undertaken to provide an empirical comparison of the two methods. The Comrey method was considerably faster but the Harman & Jones method produced higher derived communalities. Both methods gave very similar empirical rotated solutions. Implications of the results are discussed. This study was carried out in response to a question (personal communication) posed by Professor Jura Nunnally about the nature of the Comrey and Harman-Jones solutions. The authors wish to express their thanks to Harry Harman for providing a copy of his minres computer program.
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http://dx.doi.org/10.1207/s15327906mbr1304_9 | DOI Listing |
Mol Ther
January 2025
Ocular Genomics Institute, Berman-Gund Laboratory for the Study of Retinal Degenerations, Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, 02114, USA. Electronic address:
Base editing shows promise for the correction of human mutations at a higher efficiency than other repair methods and is especially attractive for mutations in large genes that are not amenable to gene augmentation therapy. Here, we demonstrate a comprehensive workflow for in vitro screening of potential therapeutic base editing targets for the USH2A gene and empirically validate the efficiency of adenine and cytosine base editor/guide combinations for correcting 35 USH2A mutations. Editing efficiency and bystander edits are compared between different target templates (plasmids versus transgenes) and assays (Next generation sequencing versus Sanger), as well as comparisons between unbiased empirical results and computational predictions.
View Article and Find Full Text PDFJMIR AI
January 2025
Department of Information Systems and Business Analytics, Iowa State University, Ames, IA, United States.
Background: In the contemporary realm of health care, laboratory tests stand as cornerstone components, driving the advancement of precision medicine. These tests offer intricate insights into a variety of medical conditions, thereby facilitating diagnosis, prognosis, and treatments. However, the accessibility of certain tests is hindered by factors such as high costs, a shortage of specialized personnel, or geographic disparities, posing obstacles to achieving equitable health care.
View Article and Find Full Text PDFEur J Cancer
January 2025
Department of Psychiatry, Psychotherapy and Psychosomatic Medicine, University Hospital of Psychiatry II, Medical University of Innsbruck, Innsbruck, Austria. Electronic address:
The European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Utility - Core 10 Dimensions (QLU-C10D) adds a preference-based scoring algorithm to the EORTC measurement portfolio. It is built on the most widely used health-related quality of life (HRQoL) measure in oncology, the EORTC Quality of Life Questionnaire - Core 30 (QLQ-C30), allowing for the calculation of both HRQoL profiles and health utilities. This is an important advancement for integrating cancer-specific values into health economic evaluations and decision making, offering greater content validity and statistical power than some generic measures.
View Article and Find Full Text PDFPLoS One
January 2025
Department of Radiology, Yantaishan Hospital, Yantai, Shandong, China.
Diabetic retinopathy, a retinal disorder resulting from diabetes mellitus, is a prominent cause of visual degradation and loss among the global population. Therefore, the identification and classification of diabetic retinopathy are of utmost importance in the clinical diagnosis and therapy. Currently, these duties are extensively carried out by manual examination utilizing the human visual system.
View Article and Find Full Text PDFBMC Palliat Care
January 2025
School of Nursing, Psychotherapy and Community Health, Faculty of Science and Health, Dublin City University, Glasnevin Campus, Dublin, D09 V209, Ireland.
Background: Due to medical advancements the number of children living with life-limiting and life-threatening conditions is rising, meaning more children and their families will require palliative and end-of-life care in the future. While 'home' is often the preferred place of end-of-life care, the evidence around best practice for decision-making about place of end-of-life care remains inadequate.
Aim: To synthesise evidence on the factors influencing decision-making regarding place of end-of-life care for children with life-limiting and life-threatening conditions.
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