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Radiomics for differential diagnosis of Bosniak II-IV renal masses via CT imaging.
BMC Cancer
December 2024
Department of Urology, Peking University Third Hospital, 49 Huayuan North Road, Haidian District, Beijing, 100191, P.R. China.
Rationale And Objectives: The management of complex renal cysts is guided by the Bosniak classification system, which may be inadequate for risk stratification of patients to determine the appropriate intervention. Radiomics models based on CT imaging may provide additional useful information.
Materials And Methods: A total of 322 patients with Bosniak II-IV cysts were included in the study from January 2010 to December 2019.
Ezrin drives adaptation of monocytes to the inflamed lung microenvironment.
Cell Death Dis
November 2024
Department of Pediatrics, School of Medicine, Yale University, New Haven, CT, USA.
Ezrin, an actin-binding protein, orchestrates the organization of the cortical cytoskeleton and plasma membrane during cell migration, adhesion, and proliferation. Its role in monocytes/macrophages (MΦs) is less understood. Here, we used a monocyte/MΦ-specific ezrin knock-out mouse model to investigate the contribution of ezrin to monocyte recruitment and adaptation to the lung extracellular matrix (ECM) in response to lipopolysaccharide (LPS).
View Article and Find Full Text PDFClinical Presentation of Cat Scratch Disease in Pediatric Patients-A Single-Center Study.
Turk Arch Pediatr
November 2024
Department of Ophthalmology, Medeniyet University Göztepe Prof. Dr. Süleyman Yalçın City Hospital, Kadıköy, İstanbul, Türkiye.
Objective: Cat scratch disease (CSD) is the infectious disease caused by Bartonella henselae. Its typical presentation is regional lymphadenopathy. Also it may present with symptoms related to involved organs or disseminated disease with fever of unknown origin (FUO).
View Article and Find Full Text PDFVon Hippel-Lindau disease with ocular and multiple systemic findings.
BMJ Case Rep
November 2024
Ophthalmology, Mata Gujri Memorial Medical College and LSK Hospital, Kishanganj, Bihar, India.
Article Synopsis
- Von Hippel-Lindau is a rare genetic disorder with an autosomal dominant inheritance pattern, leading to multiple vascular tumors, especially in the brain, eyes, and organs.
- The disease can manifest at any age, with retinal tumors often being one of the first signs; MRI and fluorescein angiography are key diagnostic tools.
- A case study highlights a woman in her late 30s with vision loss, revealing various eye and kidney abnormalities, including cystic lesions in her brain and elevated urine protein levels.
Historical Control Background Incidence of Spontaneous Nonneoplastic Lesions of Sprague Dawley Rats in 104-Week Carcinogenicity Studies.
Toxicol Pathol
October 2024
Labcorp Early Development Laboratories, Madison, Wisconsin, USA.
Article Synopsis
- A retrospective evaluation of microscopic observation data from 1800 male and female Sprague Dawley rats in 104-week carcinogenicity studies revealed common spontaneous nonneoplastic findings across different organ systems.
- The study identified frequent conditions such as cardiomyopathy, chronic nephropathy, and adrenal cortex hyperplasia among both sexes, with notable differences in prevalence.
- In male rats, chronic progressive nephropathy (80.9%) and cardiomyopathy (73.2%) were most prevalent, while in females, cystic adrenal degeneration (64.7%) and brain compression from pituitary tumors (62.7%) were common.
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