Objective: To evaluate the role of maternal factors, biomarkers, and uterine-artery Doppler in the prediction of hypertension during pregnancy.
Methods: A prospective cohort study was performed between December 2012 and November 2014. All singleton pregnancies between 11 weeks and 13 weeks, 6 days of pregnancy were included. Patients had their body mass index (BMI, calculated as weight in kilograms divided by the square of height in meters), mean arterial pressure, uterine-artery Doppler pulsatility index, and pregnancy-associated plasma protein A (PAPP-A) and free β-human chorionic gonadotropin levels recorded. Any patients diagnosed with hypertension during follow-up were assigned to the case cohort; all other patients were assigned to the control group.
Results: Hypertension during pregnancy was observed in 198 (9.7%) of 2042 patients that attended follow-up. The mean BMI, mean arterial pressure, uterine-artery Doppler pulsatility index, and the PAPP-A level at study enrollment were all significantly correlated with the later development of hypertension (P<0.001 for all variables). The combined sensitivity, specificity, positive predictive value, and negative predictive value of using the investigated parameters to predict hypertension was 76%, 80%, 31%, and 93%, respectively.
Conclusion: Patient BMI, mean arterial pressure, PAPP-A, and pulsatility index were found to be effective predictors of hypertension during pregnancy. Combining these predictors may be beneficial in selecting individuals for close monitoring and early intervention during pregnancy.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.ijgo.2015.07.021 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Acupuncture and Bushen Quyu decoction improved endometrial receptivity, hormone secretion, and uterine artery blood flow for repeated implantation failure patients undergoing in vitro fertilization and embryo transfer.
Drug Discov Ther
December 2024
Department of Obstetrics and Reproductive Immunology, Shanghai East Hospital of Tongji University, Shanghai, China.
Acupuncture and traditional Chinese medicine (TCM) have shown certain benefits in assisted in vitro fertilization and embryo transfer (IVF-ET). In this study, we evaluated the efficacy and safety of the combination of acupuncture combined with the Bushen Quyu decoction in patients with failures of IVF-ET. This study was conducted at Shanghai Yangpu District Hospital of TCM from May to November of 2021.
View Article and Find Full Text PDFProtracted maternal malnutrition induces aberrant changes in maternal uterine artery hemodynamics and the metabolic profiles of the dam and neonate.
Front Physiol
December 2024
Physiology Laboratory, Department of Animal Science, University of Nebraska-Lincoln, Lincoln, NE, United States.
Malnutritional stress during gestation is a well-established driver of metabolic disfunction in offspring. Extended exposure to malnutrition requires metabolic plasticity as the animal shifts toward a catabolic state. In this paper we demonstrate the influence of malnutrition throughout gestation on uterine artery hemodynamics and the metabolism of the dam and neonate.
View Article and Find Full Text PDFRole of routine uterine artery Doppler at 18-22 and 24-28 weeks' gestation following routine first-trimester screening for pre-eclampsia.
Ultrasound Obstet Gynecol
December 2024
Maternal Fetal Medicine Unit, Department of Obstetrics, Vall d'Hebron Barcelona Hospital Campus, Barcelona, Spain.
Objectives: To assess the performance of mean uterine artery pulsatility index (UtA-PI) at 18-22 and 24-28 weeks of gestation in the prediction of pre-eclampsia (PE) and small-for-gestational age (SGA), and its role in reassessing the risk of PE and SGA in pregnancies screened for PE in the first trimester.
Methods: This was a retrospective observational cohort study of 4464 women with singleton pregnancy screened routinely for PE in the first trimester, using the Gaussian algorithm, from March 2019 to May 2021, and who underwent UtA-PI assessment at 18-22 gestational weeks. Women were categorized as low risk or high risk based on the risk index obtained after first-trimester screening for PE.
The uterine artery resistivity index is affected by embryo resorption rate at canine pregnancy diagnosis.
Theriogenology
November 2024
Dipartimento di Scienze Veterinarie, Università di Pisa, Via Livornese (Lato Monte), 1289, San Piero a Grado, PI, Pisa, 56122, Italy.
Article Synopsis
- - The study focused on evaluating the uterine artery resistivity index (RI) through Doppler ultrasonography to assess canine fetal and placental conditions during pregnancy, particularly in relation to embryo resorption rates.
- - It examined 44 bitches of varying breeds and weights, conducting ultrasounds 25 days post-ovulation to gather data on embryo viability and resorption sites, along with factors like age and size group.
- - Statistical analysis revealed a significant relationship between the RI and gestational age and the percentage of embryo resorptions, indicating that these factors may influence uterine blood flow in pregnant dogs.
Serial evaluation of morphological and biophysical placental attributes in women with normal outcome and preeclampsia.
Int J Gynaecol Obstet
November 2024
ICMR-NICPR, Noida, UP, India.
Article Synopsis
- The study aimed to compare placental measurements and blood flow between women with preeclampsia (PE) and those with normal outcomes during pregnancy.
- It involved tracking placental dimensions and blood flow in various arteries at multiple stages of gestation, following a specific group of women until delivery.
- Results showed that women with PE had significantly smaller placental measurements and lower ratios of placental size to blood flow compared to controls, highlighting the potential of these ratios as indicators for PE risk.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!