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http://dx.doi.org/10.1111/dth.12338DOI Listing

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Article Synopsis
  • A cutaneous horn, or cornu cutaneum, is a growth made of keratinizing skin cells that often develops over underlying skin lesions such as benign and malignant tumors, infections, or other skin conditions.
  • The text describes two cases: a 22-year-old woman with a cutaneous horn linked to a stubborn wart on her toe, and a 57-year-old man with a horn associated with inverted follicular keratosis on his lip.
  • The most common conditions related to cutaneous horns are actinic keratosis, squamous cell carcinoma, and seborrheic keratosis, with several benign and malignant tumors associated with these skin growths.
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Background: Dedicator of cytokinesis protein 8 (DOCK8) deficiency is an autosomal recessive form of combined immunodeficiency. This rare disorder is characterized by an increased predisposition to allergy, autoimmunity and malignancies.

Objectives: To analyse clinical, immunological and molecular profiles of patients with DOCK8 deficiency.

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Atypical Cutaneous Viral Infections Reveal an Inborn Error of Immunity in 8 Patients.

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May 2023

Laboratory of Clinical Immunology-Inflammation and Allergy LICIA, Faculty of Medicine and Pharmacy, Hassan II University, Casablanca 20250, Morocco.

Article Synopsis
  • A study conducted at Ibn Rochd University Hospital-Casablanca from 2017 to 2021 found that unusual viral skin infections were often the first signs of inborn errors of immunity in children, affecting 1.3% of patients with suspected IEI.
  • The research involved 591 newly diagnosed patients, identifying specific genetic deficiencies like GATA2, STK4, and COPA in some, linked to chronic or resistant viral skin infections.
  • The study emphasizes the importance of recognizing these skin infections as potential indicators of underlying immunological issues, which could improve diagnosis and treatment for affected children and their families.
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Context: Molluscum contagiosum (MC) is a common viral cutaneous infection. Despite multiple treatment options, there is no definitive treatment. In some cases, the lesions are severe, recurrent, and cosmetically odd.

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