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Body mass index and waist-to-height ratio effect on mortality in non-alcoholic fatty liver: revisiting the obesity paradox.
Front Endocrinol (Lausanne)
December 2024
Department of Gastroenterology, the Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
Purpose: Emerging research indicates that individuals with non-alcoholic fatty liver disease (NAFLD) who carry excess weight have similar or even higher survival rates than their normal-weight counterparts. This puzzling "obesity paradox" may be attributed to underlying biases. To explore this phenomenon, we examined data extracted from the third National Health and Nutrition Examination Survey (NHANES) III, which spanned from 1988-1994.
View Article and Find Full Text PDFReverse-engineering the Venus figurines: An eco-life-course hypothesis for the aetiology of obesity in the Palaeolithic.
Evol Med Public Health
November 2024
Department of Obstetrics and Gynaecology, Medical University of Graz, Graz, Austria.
Evolutionary perspectives on obesity have been dominated by genetic frameworks, but plastic responses are also central to its aetiology. While often considered a relatively modern phenomenon, obesity was recorded during the Palaeolithic through small statuettes of the female form (Venus figurines). Even if the phenotype was rare, these statuettes indicate that some women achieved large body sizes during the last glacial maximum, a period of nutritional stress.
View Article and Find Full Text PDFIncreased epicardial adipose tissue is associated with left ventricular reverse remodeling in dilated cardiomyopathy.
Cardiovasc Diabetol
December 2024
Department of Cardiology, Sichuan University, Chengdu, Sichuan Province, 610041, People's Republic of China.
Background: Epicardial adipose tissue (EAT) has been suggested to play paradoxical roles in patients with heart failure. The role of EAT in dilated cardiomyopathy (DCM) patients remains unclear. We aimed to assess the associations between the dynamic changes EAT and left ventricular reverse remodeling (LVRR) in DCM patients based on baseline and follow-up CMR.
View Article and Find Full Text PDFAdipokines and Cardiometabolic Heart Failure with Preserved Ejection Fraction: A State-of-the-Art Review.
Diagnostics (Basel)
November 2024
Department of Cardiology & Heart Failure Outpatient Clinic, Sismanogleio-Amalia Fleming General Hospital, 14 25is Martiou Str., 15127 Melissia, Greece.
Background: Cardiometabolic heart failure with preserved ejection fraction (HFpEF) is largely driven by obesity-related factors, including adipokines and bioactive peptides primarily secreted by the adipose tissue, such as leptin, adiponectin, and resistin. These molecules link metabolic dysregulation to cardiovascular dysfunction, influencing HFpEF progression and patient outcomes Methods: A comprehensive literature search was conducted in PubMed up to 20 November 2024, using keywords and MeSH terms, such as "HFpEF", "adipokines", "leptin", "adiponectin", and "resistin", yielding 723 results. Boolean operators refined the search, and reference lists of key studies were reviewed.
View Article and Find Full Text PDFThe various associations between whole /regional fat mass and trajectory of cardiometabolic diseases: a nonlinear multistate model.
Obesity (Silver Spring)
January 2025
Department of Nutrition and Food Hygiene, Ministry of Education Key Laboratory of Public Health Safety, School of Public Health, Institute of Nutrition, Clinical Research Unit, Institute of Clinical Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.
Objective: This study aimed to investigate the association of whole body/regional fat mass (FM) with cardiometabolic disease (CMD) trajectory.
Methods: We conducted a prospective analysis using the UK Biobank. The FM index (FMI), a surrogate for whole body FM, and regional FM (i.
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