AI Article Synopsis
- Cytokinesis results in two independent daughter cells, and in fission yeast Schizosaccharomyces pombe, it serves as an effective model for studying its molecular control.
- This process uses an acto-myosin based contractile ring, which assembles at the cell division site influenced by spatial cues related to cell shape and the mitotic apparatus's position.
- The coordination between cytokinesis and nuclear division ensures equal distribution of cytoplasm and genetic material in daughter cells, with insights from fission yeast being applicable to other organisms that use similar mechanisms for cell division.
Article Abstract
Cytokinesis gives rise to two independent daughter cells at the end of the cell division cycle. The fission yeast Schizosaccharomyces pombe has emerged as one of the most powerful systems to understand how cytokinesis is controlled molecularly. Like in most eukaryotes, fission yeast cytokinesis depends on an acto-myosin based contractile ring that assembles at the division site under the control of spatial cues that integrate information on cell geometry and the position of the mitotic apparatus. Cytokinetic events are also tightly coordinated with nuclear division by the cell cycle machinery. These spatial and temporal regulations ensure an equal cleavage of the cytoplasm and an accurate segregation of the genetic material in daughter cells. Although this model system has specificities, the basic mechanisms of contractile ring assembly and function deciphered in fission yeast are highly valuable to understand how cytokinesis is controlled in other organisms that rely on a contractile ring for cell division.
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| http://dx.doi.org/10.1016/j.semcdb.2016.01.007 | DOI Listing |
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