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Synthetic Lipid Biology.
Chem Rev
January 2025
Weill Institute for Cell and Molecular Biology, Cornell University, Ithaca, New York 14853, United States.
Cells contain thousands of different lipids. Their rapid and redundant metabolism, dynamic movement, and many interactions with other biomolecules have justly earned lipids a reputation as a vexing class of molecules to understand. Further, as the cell's hydrophobic metabolites, lipids assemble into supramolecular structures─most commonly bilayers, or membranes─from which they carry out myriad biological functions.
View Article and Find Full Text PDFMesoscopic Morphologies in Frustrated ABC Bottlebrush Block Terpolymers.
ACS Nano
January 2025
Department of Chemistry, University of Minnesota, Minneapolis, Minnesota 55455, United States.
Article Synopsis
- Bottlebrush block polymers feature densely grafted side chains from a backbone, allowing for large ordered morphologies suitable for applications like photonic crystals.
- The study focused on creating a library of 50 triblock terpolymers (PLA-PEP-PS) through advanced polymerization techniques, leading to structures with complex phase behaviors.
- Results indicated diverse mesoscopic structures and tunable unit cell dimensions, showcasing the potential of multiblock bottlebrushes for varied material applications.
A portrait of germline pathogenic variants in high and moderate penetrance breast cancer genes in Brazil.
Front Oncol
December 2024
Oncoclinicas (OC) Medicina de Precisão (OCPM), São Paulo, Brazil.
Introduction: The prevalence of germline pathogenic/likely pathogenic variants (P/LP) in high and moderate penetrance (HMP) genes is approximately 7%-10% among breast cancer (BC) patients. The prevalence and spectrum of BC P/LP variants are affected by several factors. There are limited genetic data from Brazilian patients with BC.
View Article and Find Full Text PDFThe role of ceRNAs in breast cancer microenvironmental regulation and therapeutic implications.
J Mol Med (Berl)
December 2024
Department of Genetics and Bioengineering, Alanya Alaaddin Keykubat University, Antalya, 07425, Turkey.
The tumor microenvironment, which is the tailored physiological milieu of heterogeneous cancer cell populations surrounded by stromal and immune cells as well as extracellular matrix components, is a leading modulator of critical cancer hallmarks and one of the most significant prognostic indicators in breast cancer. In the last few decades, with the discovery of the interactions of ncRNAs with diverse cellular molecules, considerable emphasis has been devoted to understanding their direct and indirect roles in specific functions in breast cancer. Collectively, all of these have revealed that the competitive action of protein-coding RNAs and ncRNAs such as circRNAs and lncRNAs, which have a shared affinity for miRNAs, play a vital role in the molecular regulation of breast cancer.
View Article and Find Full Text PDFThe genomic portrait of the Picene culture provides new insights into the Italic Iron Age and the legacy of the Roman Empire in Central Italy.
Genome Biol
November 2024
Department of Biology and Biotechnologies 'Charles Darwin', Sapienza University of Rome, Rome, Italy.
Background: The Italic Iron Age is characterized by the presence of various ethnic groups partially examined from a genomic perspective. To explore the evolution of Iron Age Italic populations and the genetic impact of Romanization, we focus on the Picenes, one of the most fascinating pre-Roman civilizations, who flourished on the Middle Adriatic side of Central Italy between the 9 and the 3 century BCE, until the Roman colonization.
Results: More than 50 samples are reported, spanning more than 1000 years of history from the Iron Age to Late Antiquity.
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