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QseBC regulates in vitro and in vivo virulence of Aeromonas hydrophila in response to norepinephrine.
Microb Pathog
January 2023
Key Lab Freshwater Fisheries and Germplasm Resource Utilization, Ministry Agriculture, Freshwater Fisheries Research Center, Chinese Academy of Fishery Sciences, Wuxi, 214081, China.
The inter-kingdom communication between host and pathogenic bacteria mediated by the host hormones epinephrine (Epi)/norepinephrine (NE)/autoinducer-3 (AI-3) and transduced by the bacterial two-component signal transduction system QseBC has been well demonstrated in mammalian pathogens. Aeromonas hydrophila, a common opportunistic pathogen in freshwater aquaculture, responds to NE by increased bacterial growth and enhanced virulence. However, the underlying mechanisms remain poorly understood.
View Article and Find Full Text PDFGenetic Determinants of Hydrogen Sulfide Biosynthesis in Fusobacterium nucleatum Are Required for Bacterial Fitness, Antibiotic Sensitivity, and Virulence.
mBio
October 2022
Division of Oral Biology and Medicine, School of Dentistry, University of California, Los Angelesgrid.19006.3e, Los Angeles, California, USA.
The Gram-negative anaerobe Fusobacterium nucleatum is a major producer of hydrogen sulfide (HS), a volatile sulfur compound that causes halitosis. Here, we dissected the genetic determinants of HS production and its role in bacterial fitness and virulence in this important member of the oral microbiome. F.
View Article and Find Full Text PDFSelective Enhancement of the Cell-Permeabilizing Activity of Adenylate Cyclase Toxin Does Not Increase Virulence of .
Int J Mol Sci
October 2021
Institute of Microbiology of the Czech Academy of Sciences, Videnska 1083, 142 20 Prague 4, Czech Republic.
The whooping cough agent, , secretes an adenylate cyclase toxin-hemolysin (CyaA, ACT, or AC-Hly) that catalyzes the conversion of intracellular ATP to cAMP and through its signaling annihilates the bactericidal activities of host sentinel phagocytes. In parallel, CyaA permeabilizes host cells by the formation of cation-selective membrane pores that account for the hemolytic activity of CyaA. The pore-forming activity contributes to the overall cytotoxic effect of CyaA in vitro, and it has previously been proposed to synergize with the cAMP-elevating activity in conferring full virulence on in the mouse model of pneumonic infection.
View Article and Find Full Text PDF10403S Alternative Sigma-54 Factor σ Has a Negative Role on Survival Ability Under Bile Exposure.
Front Microbiol
October 2021
Department of Microbiology, Faculty of Science, Mahidol University, Bangkok, Thailand.
is a Gram-positive bacterium causing listeriosis in animals and humans. To initiate a foodborne infection, has to pass through the host gastrointestinal tract (GIT). In this study, we evaluated survival abilities of 10403S wild type (WT) and its isogenic mutants in alternative sigma (σ) factor genes (i.
View Article and Find Full Text PDF[Genomic characterization of food-borne Listeria monocytogenes isolates from Nanshan district of Shenzhen during 2009-2019].
Zhonghua Yu Fang Yi Xue Za Zhi
June 2021
Shenzhen Nanshan Center for Disease Control and Prevention, The Department of Microbiological Laboratory, Shenzhen 518054, China.
The study aims to investigate the characteristic baseline information about genetic lineages, drug-resistance genes, virulence genes and evolutionary relationships of food-borne Listeria monocytogenes (Lm) isolates from Nanshan district of Shenzhen. The whole genomes of 46 Lm isolates during 2009-2019 were extracted and sequenced (Illumina PE-150, 100×). The CLC Genomics Workbench 12.
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