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The severely injured older patient: identifying patients at high risk for mortality using the Dutch National Trauma Registry.
Eur J Trauma Emerg Surg
January 2025
Department of Surgery, Division of Trauma Surgery, Maastricht University Medical Centre, Maastricht, The Netherlands.
Purpose: The incidence of severely injured older trauma patients is increasing globally, portraying high mortality rates. Exploring the demographics and clinical outcomes of this subgroup is essential to further improve specialised care at the right place. This study was performed to identify severely injured older patients at high risk for mortality by examining their characteristics and identifying prognostic factors contributing to mortality.
View Article and Find Full Text PDFExercise interventions to improve bone mineral density in athletes participating in low-impact sports: a scoping review.
BMC Musculoskelet Disord
January 2025
Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway.
Background: Athletes participating in low-impact sports such as cycling and swimming are at increased risk for low bone mineral density, which may lead to long-term health issues. Exercise is known to increase bone mineral density, but there is little knowledge of the effects of this in athletes participating in low-impact sports. This review aims to identify potential exercise interventions that could improve bone health in these athletes.
View Article and Find Full Text PDFApproaches, Barriers, and Facilitators in Statewide Initiative to Combat Opioid Overdose: A Narrative Review of Ohio's Experiences During the HEALing Communities Study.
Prehosp Emerg Care
January 2025
Department of Emergency Medicine, MetroHealth Medical Center, Cleveland, Ohio.
Objectives: Opioid-associated fatal and non-fatal overdose rates continue to rise. Prehospital overdose education and naloxone distribution (OEND) programs are attractive harm-reduction strategies, as patients who are not transported by EMS after receiving naloxone have limited access to other interventions. This narrative summary describes our experiences with prehospital implementation of evidence-based OEND practices across Ohio as part of the HEALing Communities Study (HCS).
View Article and Find Full Text PDFAntibody-Drug Conjugates in Breast Cancer: The Road Towards Biologically-Informed Selection and Sequencing.
Curr Oncol Rep
January 2025
Susan F. Smith Center for Women's Cancers, Breast Oncology Program, Department of Medical Oncology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA, USA.
Purpose Of Review: In this review, we discuss evidence supporting the use of antibody-drug conjugates (ADCs) in breast cancer treatment, describe novel ADCs and combination regimens under development, and examine our current understanding of resistance mechanisms and biomarkers to guide ADC selection and sequencing.
Recent Findings: Three ADCs have proven benefit in patients with metastatic breast cancer: trastuzumab emtansine (T-DM1), trastuzumab deruxtecan (T-DXd), and sacituzumab govitecan (SG). There are over two hundred investigational ADCs on the horizon, as pre-clinical studies work to identify novel ADC targets and structures.
The MuCAYA Study-Influence of Physical Activity and Metabolic Parameters on the Structure and Function of the Cardiovascular System in Young Athletes.
CJC Open
December 2024
Department of Health and Sport Sciences, Institute of Preventive Pediatrics, Technical University of Munich (TUM) School of Medicine and Health, TUM, Munich, Germany.
Exercise has a significant impact on the cardiovascular (CV) health of children and adolescents, with resultant alterations in CV structure and function being evident, even at an early age. Engagement in regular, moderate physical activity (PA) is associated with long-term CV health benefits and a reduced risk of CV disease and mortality later in life. However, competitive sports often involve PA training intensities that are beyond recommended levels for young athletes, potentially leading to adverse CV outcomes.
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