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Novel Natural Candidates for Replacing Synthetic Additives in Nutraceutical and Pharmaceutical Areas: Two Species ( (L.) Roxb. and (L.) Link).
Food Sci Nutr
January 2025
Department of Plant Physiology, Institute for Biological Research "Siniša Stanković" - National Institute of Republic of Serbia University of Belgrade Belgrade Serbia.
(L.) Roxb. and (L.
View Article and Find Full Text PDFHyaluronic Acid-Based Hybrid Nanoparticles as Promising Carriers for the Intranasal Administration of Dimethyl Fumarate.
Int J Nanomedicine
January 2025
Department of Medicine, Surgery and Pharmacy, University of Sassari, Sassari, Italy.
Purpose: Dimethyl fumarate (DMF), the first-line oral therapy for relapsing-remitting multiple sclerosis, is rapidly metabolized into monomethyl fumarate. The DMF oral administration provokes gastrointestinal discomfort causing treatment withdrawal. The present study aimed to develop an innovative formulation for DMF nasal administration.
View Article and Find Full Text PDFInterventions used to reduce infectious aerosol concentrations in hospitals-a review.
EClinicalMedicine
January 2025
WEISS Centre, University College London, UK.
Background: The COVID-19 pandemic highlighted the need for improved infectious aerosol concentrations through interventions that reduce the transmission of airborne infections. The aims of this review were to map the existing literature on interventions used to improve infectious aerosol concentrations in hospitals and understand challenges in their implementation.
Methods: We reviewed peer-reviewed articles identified on three databases, MEDLINE, Web of Science, and the Cochrane Library from inception to July 2024.
An integrated approach to uncertainty and global sensitivity analysis in penstock structural modeling.
Heliyon
January 2025
Department of Mechanical Engineering, Mohammadia School of Engineering, Avenue Ibn Sina B.P 765, Agdal, Rabat, 10090, Morocco.
Enhanced penstock structural models significantly advance hydropower engineering, yet their increasing complexity introduces challenges. As model interactions intensify, predictability and comprehensibility decrease, complicating the evaluation of model accuracy and alignment with operational performance metrics and safety standards. This issue is particularly pronounced in dynamic modeling, where knowledge gaps hinder straightforward validation via observational data.
View Article and Find Full Text PDFThe tumor microenvironment (TME) is critical for cancer initiation, growth, metastasis, and therapeutic resistance. The extracellular matrix (ECM) is a significant tumor component that serves various functions, including mechanical support, TME regulation, and signal molecule generation. The quantity and cross-linking status of ECM components are crucial factors in tumor development, as they determine tissue stiffness and the interaction between stiff TME and cancer cells, resulting in aberrant mechanotransduction, proliferation, migration, invasion, angiogenesis, immune evasion, and treatment resistance.
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