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| http://dx.doi.org/10.1371/journal.pntd.0004244 | DOI Listing |
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High risk and low incidence diseases: Massive hemoptysis.
Am J Emerg Med
November 2024
SAUSHEC, Department of Emergency Medicine, Brooke Army Medical Center, Fort Sam Houston, TX, USA. Electronic address:
Article Synopsis
- * The primary causes of MH include tuberculosis globally, with other common causes like bronchiectasis and lung cancer prevalent in the U.S.; rapid assessment and necessary interventions are vital to prevent deterioration in patients.
- * Effective management involves initial stabilization, airway assessment, correcting coagulation issues, advanced imaging through CT angiography, and collaboration with specialists in pulmonary and surgical fields to ensure patient safety and recovery.
Two dose levels of once-weekly fosravuconazole versus daily itraconazole in combination with surgery in patients with eumycetoma in Sudan: a randomised, double-blind, phase 2, proof-of-concept superiority trial.
Lancet Infect Dis
November 2024
Drugs for Neglected Diseases initiative (DNDi), Geneva, Switzerland.
Background: Eumycetoma is an implantation mycosis characterised by a large subcutaneous mass in the extremities commonly caused by the fungus Madurella mycetomatis. Despite the long duration of treatment, commonly a minimum of 12 months, treatment failure is frequent and can lead to amputation. We aimed to compare the efficacy of two doses of fosravuconazole, a synthetic antifungal designed for use in onychomycosis and repurposed for mycetoma, with standard-of-care itraconazole, both in combination with surgery.
View Article and Find Full Text PDFImpact of COVID-19 on the neglected tropical diseases: a scoping review.
Infect Dis Poverty
July 2024
Infection Medicine, Edinburgh Medical School: Biomedical Sciences, College of Medicine and Veterinary Medicine, The University of Edinburgh, 1 George Square, Edinburgh, EH8 9TB, Scotland, UK.
Article Synopsis
- This study examines how the COVID-19 pandemic has impacted neglected tropical diseases (NTDs), focusing on funding and program management, and evaluates potential delays to the Sustainable Development goals for elimination of these diseases.
- Researchers used data from various official sources like the World Health Organization and government aid documents to analyze the pandemic's effects on NTD management, funding, and barriers faced by low and middle-income countries.
- Results show that the pandemic caused significant disruptions in NTD programs, leading to a decline in research and development funding, and negatively affecting the progress towards eliminating these diseases, especially in poorer populations.
Eumycetoma causative agents: A systematic review to inform the World Health Organization priority list of fungal pathogens.
Med Mycol
June 2024
Department of Infectious Diseases, The Alfred and Monash University, Melbourne, Victoria, Australia.
The World Health Organization, in response to the growing burden of fungal disease, established a process to develop a fungal priority pathogens list. This systematic review aimed to evaluate the epidemiology and impact of eumycetoma. PubMed and Web of Science were searched to identify studies published between 1 January 2011 and 19 February 2021.
View Article and Find Full Text PDFMany faces of cutaneous leishmaniasis.
Postgrad Med J
September 2024
Department of Medical Microbiology, Harran University Medical Faculty, Şanlıurfa 63000, Turkey.
Article Synopsis
- This study aimed to identify atypical clinical presentations of cutaneous leishmaniasis (CL) in Şanlıurfa province, encompassing a retrospective analysis of 213 patients with non-standard symptoms out of 1,751 diagnosed cases between 2019 and 2022.
- The prevalence of atypical CL was found to be 12.1%, with common atypical lesions including lupoid, erysipeloid, and impetiginous types, along with many others resembling various skin conditions and diseases.
- The research highlights that CL can mimic a wide range of infectious, inflammatory, and neoplastic disorders, stressing the importance of thorough differential diagnosis for persistent non-healing skin lesions, especially in areas where CL is
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