AI Article Synopsis
- Osteoradionecrosis (ORN) is a serious complication of radiotherapy that is challenging to treat after it occurs.
- Recent research suggests that using pentoxifylline and vitamin E may help manage ORN effectively.
- A study of 62 patients showed a 56% success rate with just pentoxifylline and vitamin E, but only a 27% success rate when combined with antibiotics, indicating the need for further randomized clinical trials to compare these treatments.
Article Abstract
Osteoradionecrosis (ORN) is a complication of radiotherapy, and is difficult to manage once established. However, its pathogenesis has been reinvestigated, and it is now thought to be potentially amenable to treatment with pentoxifylline and tocopherol (vitamin E). We made a retrospective analysis of 62 patients with established ORN who were treated in this way. When only pentoxifylline and vitamin E was used ORN resolved in 14/25 (56%) but paradoxically, when it was combined with antibiotics, only 6/22 resolved (27%). The next stage would ideally be to incorporate the treatment in a randomised clinical trial against both standard antibiotic treatment and hyperbaric oxygen.
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| http://dx.doi.org/10.1016/j.bjoms.2015.11.027 | DOI Listing |
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