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http://dx.doi.org/10.3389/fnint.2015.00068 | DOI Listing |
JAMA
November 2024
Duke Clinical Research Institute and Division of Cardiology, Duke University, Durham, North Carolina.
Importance: The emergence of novel programming guidelines that reduce premature and inappropriate therapies along with the availability of new implantable cardioverter-defibrillator (ICD) technologies lacking traditional endocardial antitachycardia pacing (ATP) capabilities requires the reevaluation of ATP as a first strategy in terminating fast ventricular tachycardias (VTs) in primary prevention ICD recipients.
Objective: To assess the role of ATP in terminating fast VTs in primary prevention ICD recipients with contemporary programming.
Design, Setting, And Participants: This global, prospective, double-blind, randomized clinical trial had an equivalence design with a relative margin of 35%.
Eur Arch Otorhinolaryngol
December 2024
Audiology Programme, School of Health Sciences, Universiti Sains Malaysia, Kelantan, Malaysia.
Cancer Discov
October 2024
The Francis Crick Institute, London, United Kingdom.
Tumors frequently display high chromosomal instability and contain multiple copies of genomic regions. Here, we describe Gain Route Identification and Timing In Cancer (GRITIC), a generic method for timing genomic gains leading to complex copy number states, using single-sample bulk whole-genome sequencing data. By applying GRITIC to 6,091 tumors, we found that non-parsimonious evolution is frequent in the formation of complex copy number states in genome-doubled tumors.
View Article and Find Full Text PDFFundam Res
May 2024
State Key Laboratory of Nuclear Physics and Technology, School of Physics, Peking University, Beijing 100871, China.
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