AI Article Synopsis
- Dengue fever poses a significant public health threat in Brazil, leading to serious outbreaks and health complications.
- This study examines maternal and fetal deaths linked to dengue, analyzing tissues from the placenta and umbilical cord using advanced molecular techniques.
- The presence of dengue virus markers in these tissues suggests that they could serve as valuable tools in investigating fatal cases of dengue, particularly those affecting mothers and their unborn children.
Article Abstract
In Brazil, dengue is a public health problem with the occurrence of explosive epidemics. This study reports maternal and fetal deaths due to dengue and which tissues of placenta and umbilical cord were analyzed by molecular methods and immunohistochemistry. The dengue NS3 and NS1 detection revealed the viral presence in different cells from placenta and umbilical cord. In the latter, DENV-2 was detected at a viral titer of 1,02 × 10(4) amounts of viral RNA. It was shown that the DENV markers analyzed here may be an alternative approach for dengue fatal cases investigation, especially involving maternal and fetal death. J. Med. Virol. 88:1448-1452, 2016. © 2016 Wiley Periodicals, Inc.
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| http://dx.doi.org/10.1002/jmv.24479 | DOI Listing |
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