AI Article Synopsis
- Recent research shows that hypoxia-inducible VEGF has protective effects on brain cells, and coffee consumption may lower the risk of neurological disorders.
- A study on human neuroblastoma cells revealed that even low concentrations of coffee significantly increase VEGF expression through HIF-1α activation.
- The active component responsible for this activation isn't found in common coffee constituents but emerges during the roasting process, indicating that daily coffee consumption could support brain health and protect against diseases like Alzheimer's and Parkinson's.
Article Abstract
Recent evidence indicates that hypoxia-inducible vascular endothelial growth factor (VEGF) has neurotrophic and neuroprotective effects on neuronal and glial cells. On the other hand, recent epidemiological studies showed that daily coffee consumption has been associated with a lower risk of several neuronal disorders. Therefore, we investigated the effect of coffee on VEGF expression in human neuroblastoma SH-SY5Y cells. We found that even low concentration of coffee (<2%) strongly induced VEGF expression via an activation of HIF-1α. The activation of HIF-1α by coffee was attributed to the coffee-dependent inhibition of prolyl hydroxylation of HIF1α, which is essential for proteolytic degradation of HIF-1α. However, no inhibition was observed at the catalytic activity in vitro. Coffee component(s) responsible for the activation of HIF-1α was not major constituents such as caffeine, caffeic acid, chlorogenic acid, and trigonelline, but was found to emerge during roasting process. The active component(s) was extractable with ethyl acetate. Our results suggest that daily consumption of coffee may induce VEGF expression in neuronal cells. This might be related to protective effect of coffee on neural disorders such as Alzheimer's disease and Parkinson's disease.
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| http://dx.doi.org/10.1080/1028415X.2015.1133106 | DOI Listing |
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