AI Article Synopsis
- - The study examined the usefulness of neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) in predicting how patients with advanced gastric cancer respond to chemotherapy and their overall survival.
- - Results showed that patients with low baseline NLR and PLR had better tumor characteristics and improved responses to chemotherapy, while those with high levels had worse survival rates.
- - Changes in NLR and PLR after chemotherapy also correlated with treatment effectiveness and prognosis, indicating that monitoring these ratios can help predict outcomes for patients with unresectable gastric cancer.
Article Abstract
The aim of the study was to investigate the application value of neutrophil to lymphocyte ratio (NLR) and the platelet to lymphocyte ratio (PLR) in the prediction of chemotherapy response and prognosis in patients with advanced gastric cancer. In total, 120 patients with unresectable gastric cancer were included and separated into two groups according to the median values of NLR or PLR (NLR low: <4.62 or NLR high: ≥4.62 and PLR low: <235 or PLR high: ≥235, respectively). Low baseline NLR level correlated with improved clinicopathological characteristics, including smaller tumor size, well differentiation and less metastasis. Low baseline PLR level also associated with less metastasis. Patients with a low baseline level of NLR or PLR had an improved response to chemotherapy. Patients with a higher baseline NLR and PLR had decreased progression-free survival (PFS) and overall survival (OS) ratios. Alterations in the NLR and PLR levels were associated with therapeutic efficacy and prognosis. The patients who remained in or switched to the low NLR level subgroup subsequent to first-line chemotherapy had an improved response and improved OS ratios, compared to the patients remaining in or switching to the high NLR level group. Similar results were observed when the PLR level was investigated. In conclusion, baseline NLR and PLR measurements, as well as changes of NLR and PLR following chemotherapy can predict the prognostic results in patients with unresectable gastric cancer.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4665714 | PMC |
| http://dx.doi.org/10.3892/ol.2015.3783 | DOI Listing |
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