AI Article Synopsis
- The study examined whether changes in mean platelet volume (MPV) could predict total mortality in patients with non-ST-segment elevation myocardial infarction (NSTEMI).
- The research involved analyzing 419 patients, where 49 were identified as nonsurvivors during a 1-year follow-up, revealing that both MPV and the change in MPV (ΔMPV) were significantly higher in those who did not survive.
- Final analysis showed that an early increase in ΔMPV serves as an independent predictor of total mortality, suggesting that NSTEMI patients may require more effective antiplatelet therapy.
Article Abstract
It is unclear whether changes in mean platelet volume (MPV) are associated with total mortality in acute coronary syndromes. We investigated whether the change in MPV predicts total mortality in patients with non-ST-segment elevation myocardial infarction (NSTEMI). We retrospectively analyzed 419 consecutive patients (19 patients were excluded). The remaining patients were categorized as survivors (n = 351) or nonsurvivors (n = 49). Measurements of MPV were performed at admission and after 24 hours. The difference between the 2 measurements was considered as the MPV change (ΔMPV). The end point of the study was total mortality at 1-year follow-up. During the follow-up, there were 49 deaths (12.2%). Admission MPV was comparable in the 2 groups. However, both MPV (9.6 ± 1.4 fL vs 9.2 ± 1.0 fL, P = .044) and ΔMPV (0.40 [0.10-0.70] fL vs 0.70 [0.40-1.20] fL, P < .001) at the first 24 hours were higher in nonsurvivors than survivors. In multivariate analysis, ΔMPV was an independent predictor of total mortality (odds ratio: 1.84, 95% confidence interval: 1.28-2.65, P = .001). An early increase in MPV after admission was independently associated with total mortality in patients with NSTEMI. Such patients may need more effective antiplatelet therapy.
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| http://dx.doi.org/10.1177/0003319715627734 | DOI Listing |
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