Background: Oocyte donation is a medical technique used principally for woman with ovarian failure. Optimizing donor recruitment is essential to obtain the best results with this technique. Understanding how donor parameters influence outcome for the recipients is fundamental. The aim of this study was to determine whether clinical and/or biological parameters in the donors influence the chance of pregnancy in recipients. Our objective was also to verify whether the outcomes of controlled ovarian stimulation (COS) are predictive of pregnancy in the recipients.
Methods: A retrospective observational study was conducted in the Department of Reproductive Medicine in the Lille University Hospital. Between September 2005 and April 2014, COS was performed in 145 donors for 308 recipients' cycles. We compared the cycles whose outcome was pregnancy to the cycles without pregnancy. Quantitative variables were compared using the nonparametric Mann-Whitney test. Qualitative variables were compared using a Chi-2 test or Fisher exact test, according to the numbers. Covariance analysis was performed to adjust for potential confounding factors.
Results: The donors who produced at least one pregnancy had a mean baseline serum anti-Müllerian hormone (AMH) level significantly higher than those who did not (p = 0.001). The mean antral follicle count did not differ between the 2 groups. After covariance analysis controlling for the number of couples attributed to a given donor, this difference remained significant (p = 0.029). Mature follicle number, estradiol serum level at the trigger day, number of mature oocytes and embryo number were significantly higher in the donors who produced pregnancy.
Conclusion: Serum AMH level is associated with pregnancy outcome after oocyte donation.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4717601 | PMC |
http://dx.doi.org/10.1186/s12958-016-0138-0 | DOI Listing |
Gynecol Obstet Fertil Senol
December 2024
Endocrinologue-Diabétologue, chef de service d'Endocrinologie, Hôpital l'Archet, CHU Nice, 151 route de Saint Antoine de Ginestière, 06 200 NICE, France. Electronic address:
Objectives: The Bioethics Law of August 2nd, 2021 established access to origins for people conceived by gamete donation. Two years after the implementation of this disposition, what is the proportion of former gamete donors informed about access to origins, and what is their position on this matter? What could be the potential repercussions of this new law on them? .
Methods: Retrospective single-center cohort study using questionnaires Results: When former gamete donors were asked about access to origins, only 53 % of oocytes donors and 71 % of sperm donors were aware of this measure.
J Assist Reprod Genet
December 2024
Departament of Reproductive Medicine, Instituto Bernabeu, Alicante, Spain.
Purpose: To compare the efficacy of modified natural cycle (mNC) preparation versus hormone replacement therapy (HRT) for endometrial preparation in recipients of donated oocytes, specifically focusing on pregnancy rates in women of advanced maternal age.
Methods: Retrospective multicenter analysis conducted between 2021 and 2024. It includes 220 cycles of fresh single blastocyst transfers resulting from oocyte donation.
Reprod Biomed Online
September 2024
Department of Psychology, Umeå University, Umeå, Sweden.
Research Question: Do directed oocyte donors differ from non-directed identity-release oocyte donors regarding pre-donation motives and ambivalence, and post-donation satisfaction and openness?
Design: The study is part of the longitudinal Swedish Study on Gamete Donation where consecutive samples of identity-release gamete donors at seven Swedish University Hospitals were approached during a 3-year period (2005-2008). The participants of the current study were 16 women who donated oocytes to family members or friends (directed donation) and 123 women who donated to unknown recipients (non-directed donation). Survey data on motivation, ambivalence, post-donation satisfaction and openness were collected at five time points between acceptance as a donor and 14-17 years post-donation.
JBRA Assist Reprod
December 2024
Genetics Unit, Department of Pathology, University of Porto, Alameda Professor Hernâni Monteiro, 4200-319, Porto, Portugal.
Objective: There is a rising demand for assisted reproductive medicine, including sperm, oocyte and embryo donation. Besides medical and legal considerations, genetic testing, including carrier screening for multiple autosomal and X-linked recessive disorders plays an essential role in evaluating hereditary risk among donors and therefore exclude them from the donation process.
Methods: A retrospective study was conducted on oocyte donors from a private clinic of assisted reproduction who underwent genetic testing between June 2014 and September 2023.
Fertil Steril
December 2024
IVF Unit, Department of Obstetrics and Gynecology, Meir Medical Center, Kfar Saba, Israel; School of Medicine, Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel; Department of Obstetrics and Gynecology, Mayanei Hayeshua Medical Center, Bnei Brak, Israel. Electronic address:
Objective: To study the perinatal outcomes of children born from different conception methods: in vitro fertilization (IVF) with autologous oocytes or IVF with donor egg vs. those conceived without medical assistance by using a sibling analysis.
Design: Retrospective cohort study conducted using electronic medical record data from 2000 through 2018, of a national healthcare organization.
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