Specific proteolytic and antitryptic activities were measured in the sinus exudate of 27 patients with chronic suppurative maxillary sinusitis. Most patients showed a shift in the proteinase-inhibitor system with proteolytic activity being predominant. In the course of treatment antitryptic activity in the exudate increased. It was found that biochemical data were correlated with clinical manifestations. It is concluded that patients with the above pathology should be prescribed proteolytic enzymes on an individual basis and that natural proteinase inhibitors should be included into the combined therapy.
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