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Evolutionary Rationale for Phages as Complements of Antibiotics. | LitMetric

Evolutionary Rationale for Phages as Complements of Antibiotics.

Trends Microbiol

Institut des Sciences de l'Evolution, Université Montpellier, Place E Bataillon 34095, Montpellier, France; Santa Fe Institute, 1399 Hyde Park Road, Santa Fe, NM 87501, USA. Electronic address:

Published: April 2016

AI Article Synopsis

Article Abstract

Antibiotic-resistant bacterial infections are a major concern to public health. Phage therapy has been proposed as a promising alternative to antibiotics, but an increasing number of studies suggest that both of these antimicrobial agents in combination are more effective in controlling pathogenic bacteria than either alone. We advocate the use of phages in combination with antibiotics and present the evolutionary basis for our claim. In addition, we identify compelling challenges for the realistic application of phage-antibiotic combined therapy.

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Source
http://dx.doi.org/10.1016/j.tim.2015.12.011DOI Listing

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