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RGX Ensemble Model for Advanced Prediction of Mortality Outcomes in Stroke Patients.
BME Front
November 2024
Faculty of Information Science and Technology, Beijing University of Technology, Beijing 100020, China.
Article Synopsis
- The paper presents RGX, a comprehensive model developed to better predict outcomes for stroke patients, enabling more personalized treatment plans.
- It incorporates the SHAP model to clarify how various patient factors influence mortality predictions, addressing current gaps in understanding which clinical variables affect survival.
- The RGX model shows impressive accuracy rates of 92.18% with complete data and 84.62% with significant missing data, outperforming existing models and supporting the advancement of precision medicine.
Impaired oxytocin signalling in the central amygdala in rats with chronic heart failure.
J Physiol
November 2024
Center for Neuroinflammation and Cardiometabolic Diseases, Georgia State University, Atlanta, GA, USA.
Heart failure (HF) patients suffer from cognitive decline and mood impairments, but the molecular signals and brain circuits underlying these effects remain elusive. The hypothalamic neuropeptide oxytocin (OT) is critically involved in regulating mood, and OTergic signalling in the central amygdala (CeA) is a key mechanism that controls emotional responses including anxiety-like behaviours. Still, whether an altered OTergic signalling contributes to mood disorders in HF remains unknown.
View Article and Find Full Text PDFNeurological Complications of COVID-19: Unraveling the Pathophysiological Underpinnings and Therapeutic Implications.
Viruses
July 2024
Department of Pathology, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus disease (COVID-19), induced a global pandemic with a diverse array of clinical manifestations. While the acute phase of the pandemic may be waning, the intricacies of COVID-19's impact on neurological health remain a crucial area of investigation. Early recognition of the spectrum of COVID-19 symptoms, ranging from mild fever and cough to life-threatening respiratory distress and multi-organ failure, underscored the significance of neurological complications, including anosmia, seizures, stroke, disorientation, encephalopathy, and paralysis.
View Article and Find Full Text PDFVariations in Cortical Oxygenation by Near-Infrared Spectroscopy According to Head Position after Acute Stroke: The Preliminary Findings of an Observational Study.
J Clin Med
July 2024
Department of Neuroscience and Rehabilitation, University of Ferrara, 44124 Ferrara, Italy.
: After ischemic stroke, there is no general consensus on the optimal position for the head of patients in the acute phase. This observational study aimed to measure the variations in cortical oxygenation using noninvasive functional near-infrared spectroscopy (fNIRS) at different degrees of head positioning on a bed. : Consecutive ischemic stroke patients aged 18 years or older with anterior circulation ischemic stroke within 48 h of symptom onset who could safely assume different positions on a bed were included.
View Article and Find Full Text PDFUnraveling dynamic immunological landscapes in intracerebral hemorrhage: insights from single-cell and spatial transcriptomic profiling.
MedComm (2020)
July 2024
Department of Neurosurgery Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China.
Intracerebral hemorrhage (ICH) poses a formidable challenge in stroke management, with limited therapeutic options, particularly in the realm of immune-targeted interventions. Clinical trials targeting immune responses post-ICH have encountered setbacks, potentially attributable to the substantial cellular heterogeneity and intricate intercellular networks within the brain. Here, we present a pioneering investigation utilizing single-cell RNA sequencing and spatial transcriptome profiling at hyperacute (1 h), acute (24 h), and subacute (7 days) intervals post-ICH, aimed at unraveling the dynamic immunological landscape and spatial distributions within the cerebral tissue.
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