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Dysregulation of Airway and Systemic Interferon Responses Promote Asthma Exacerbations in Urban Children.
J Allergy Clin Immunol
January 2025
Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI.
Background: Determining why some upper respiratory illnesses provoke asthma exacerbations remains an unmet need.
Objective: To identify transcriptome-wide gene expression changes associated with colds that progress to exacerbation.
Methods: 208 urban children (6-17 years) with exacerbation-prone asthma were prospectively monitored for up to two cold illnesses.
Patient and physician expectations regarding disease and treatment of advanced HCC: The prospective PERCEPTION1 study.
JHEP Rep
November 2024
Liver unit, Beaujon Hospital, APHP Clichy, France.
Background & Aims: We aimed to explore patient expectations regarding their treatments and prognosis in comparison to physicians' assessments in patients with advanced hepatocellular carcinoma (HCC) receiving systemic treatments.
Methods: We prospectively enrolled 205 patients in France and Belgium with Barcelona Clinic Liver Cancer (BCLC) stage B/C HCC receiving systemic treatment (NCT04823754). Patients completed a 28-question survey and the hospital anxiety and depression scale (HADS), while physicians filled a 17-question survey after the initial consultation.
Amoxicillin Blood Concentration in High-Dose Intravenous Discontinuous Amoxicillin: Look Beyond Numbers. Max-Amox Study.
Clin Ther
December 2024
Department of Infectious Diseases, CHU Clermont-Ferrand, Clermont-Ferrand, France. Electronic address:
Purpose: High doses of amoxicillin are recommended to treat severe infections such as endocarditis. Amoxicillin causes dose-dependent toxicities, in particular crystal nephropathy. Toxicity could be avoided by monitoring of amoxicillin trough plasma concentrations (ATPC).
View Article and Find Full Text PDFOptimizing Mainstreaming of Genetic Testing in Parallel With Ovarian and Endometrial Cancer Tumor Testing: How Do We Maximize Our Impact?
JCO Precis Oncol
December 2024
Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY.
Article Synopsis
- Germline genetic testing (GT) is recommended for ovarian cancer (OC) and some endometrial cancer (EC) patients, but participation is low due to various barriers.
- A quality improvement study at a medical center tracked 116 newly diagnosed OC/EC patients, achieving high GT rates (91% for OC, 75% for EC) and rapid result availability.
- Identified barriers include missed recommendations, patient overwhelm, financial/privacy concerns, and language issues; the study suggests enhancing GT encouragement throughout treatment and offering multilingual digital consent options.
The provision of echocardiography in critical care: a multi-centre survey of the UK and Crown Dependencies.
Intensive Care Med
December 2024
Department of Perioperative Medicine, Barts Health NHS Trust, London, UK.
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