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Exploring the mechanism of luteolin improving immune and inflammatory responses in systemic sclerosis based on systems biology and cell experiments.
Int Immunopharmacol
September 2024
First Clinical Medical College, Anhui University of Traditional Chinese Medicine, Hefei, Anhui 230031, PR China; Department of Rheumatology and Immunology, First Affiliated Hospital of Anhui University of Traditional Chinese Medicine, Shushan, Hefei, Anhui 230038, PR China.
There is a growing trend of applying traditional Chinese medicine (TCM) to treat immune diseases. This study reveals the possible mechanism of luteolin, an active ingredient in the core prescription of TCM, in alleviating systemic sclerosis (SSc) inflammation. Bibliometrics was performed to retrieve the core keywords of SSc inflammation.
View Article and Find Full Text PDFAdult-onset neuronal intranuclear inclusion disease related retinal degeneration: a Chinese case series.
Front Med (Lausanne)
January 2024
Department of Ophthalmology, Eye Ear Nose and Throat Hospital of Fudan University, Shanghai, China.
Purpose: To evaluate adult-onset neuronal intranuclear inclusion disease (NIID)-related retinopathy with guanine-guanine-cytosine repeat expansions in .
Materials And Methods: Neuro-ophthalmic evaluations, including best-corrected visual acuity, slit-lamp biomicroscopy, intraocular pressure (IOP), ultrasound biomicroscopy, pupillometry, fundus photography, fundus autofluorescence (FAF), optical coherence tomography (OCT), Humphrey visual field, full-field electroretinography (ERG), and multifocal ERG (mf-ERG) were performed in patients with gene-proven NIID.
Results: Nine patients (18 eyes) were evaluated, with a median age of 62 years (55-68) and only one man was included in our study.
Article Synopsis
- The growth of molecular genetic testing is speeding up the discovery of new disease-causing genes and expanding the symptoms linked to known genes, particularly in genetic movement disorders.
- Certain movement disorders are more common in specific ethnic groups, indicating that genetics and clinical presentations can vary across populations.
- The Movement Disorders in Asia Task Force focuses on genetic movement disorders prevalent in Asia, such as Wilson's disease and various types of ataxias, and considers how specific mutations may present differently in Asian patients compared to global averages.
Diagnosis and phylogenetic analysis of bovine papillomaviruses in cattle papillomatosis cases by different methods.
Trop Anim Health Prod
May 2023
Department of Virology, Faculty of Veterinary Medicine, Burdur Mehmet Akif Ersoy University, 15100, Burdur, Turkey.
Papillomaviruses, known as epitheliotropic, cause proliferation in the skin, mucosa, and different visceral organs. In this study, it was aimed to diagnose bovine papillomavirus (BPV) by using different methods in the lesion taken from twenty cattle with papillomas in different areas of the body and to reveal its molecular characterization. In our study, molecular, immunohistochemistry, and transmission electron microscopy (TEM) methods were used for virus identification.
View Article and Find Full Text PDFCharacteristic cerebral perfusion pattern in neuronal intranuclear inclusion disease.
Front Neurosci
December 2022
Department of Radiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Background: Neuronal intranuclear inclusion disease (NIID), which pathogenesis remains largely unclear, is a neurodegenerative disease caused by GGC repeat expansion in gene. As case studies have reported dynamic cortical perfusion changes in NIID, this study aimed to explore the cerebral perfusion pattern in NIID patients.
Materials And Methods: A total of 38 NIID patients and 34 healthy controls (HCs) were recruited, and 2 NIID patients who had had episodic symptoms within 2 months were excluded.
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