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SNPing away to individualize induction therapy for acute myelogenous leukemia.
Leuk Lymphoma
August 2016
a Robert H. Lurie Comprehensive Cancer Center, Division of Hematology/Oncology , Northwestern Medicine Developmental Therapeutics Institute, Feinberg School of Medicine, Northwestern University, Chicago , IL , USA ;
OS077. The chromosome 2q22 preeclampsia susceptibility locus reveals shared novel risk factors for CVD.
Pregnancy Hypertens
July 2012
University of Melbourne, Melbourne, Australia.
Introduction: We have previously localized a preeclampsia susceptibility locus on chromosome 2q22 in 34 Australian and New Zealand (AUS/NZL) families. Using an extended number of AUS/NZL families (n=74) we have now performed a comprehensive molecular genetics dissection of this locus.
Objectives: Identify causal genetic risk factors for preeclampsia at the 2q22 risk locus.
SNPing away at candidate genes.
Genet Epidemiol
April 2002
Department of Biomathematics, University of California at Los Angeles, Los Angeles, California, USA.
We develop regression methodology to identify subsets of single nucleotide polymorphisms (SNPs) within candidate genes related to quantitative traits and apply our methods to the simulated Genetic Analysis Workshop (GAW) 12 data set. In the data set we find 694 SNP loci with minimum allele frequencies of at least 0.01.
View Article and Find Full Text PDFSNPing away at complex diseases: analysis of single-nucleotide polymorphisms around APOE in Alzheimer disease.
Am J Hum Genet
August 2000
Department of Medicine and Center for Human Genetics, Duke University Medical Center, Durham, NC, 27710, USA. duke.edu
There has been great interest in the prospects of using single-nucleotide polymorphisms (SNPs) in the search for complex disease genes, and several initiatives devoted to the identification and mapping of SNPs throughout the human genome are currently underway. However, actual data investigating the use of SNPs for identification of complex disease genes are scarce. To begin to look at issues surrounding the use of SNPs in complex disease studies, we have initiated a collaborative SNP mapping study around APOE, the well-established susceptibility gene for late-onset Alzheimer disease (AD).
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