AI Article Synopsis
- Baicalin (BA), a flavonoid from Scutellaria baicalensis, shows strong antiviral effects, particularly against the influenza virus A/PR/8/34 (H1N1).
- The study highlights that BA protects mice from infection by increasing IFN-γ production, but is ineffective in mice lacking IFN-γ or its receptor.
- Additionally, BA stimulates human T cells and natural killer (NK) cells to produce IFN-γ and activates the JAK/STAT-1 signaling pathway, confirming its antiviral potential both in vitro and in vivo.
Article Abstract
Baicalin (BA) is a flavonoid compound purified from Scutellaria baicalensis Georgi and has been shown to possess a potent inhibitory activity against viruses. However, the role of BA in anti-influenza virus has not been extensively studied, and the immunological mechanism of BA in antiviral activity remains unknown. Here, we observed that BA could protect mice from infection by influenza virus A/PR/8/34 (H1N1), associated with increasing IFN-γ production, but presented no effects in IFN-γ or IFN-γ receptor deficient mice. Further study indicated that BA could inhibit A/PR/8/34 replication through IFN-γ in human PBMC. Moreover, BA can directly induce IFN-γ production in human CD4(+) and CD8(+) T cells and NK cells, and activate JAK/STAT-1 signaling pathway. Collectively, BA exhibited anti-influenza virus A (H1N1) activity in vitro and in vivo as a potent inducer of IFN-γ in major IFN-γ producing cells.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4689896 | PMC |
| http://dx.doi.org/10.1155/2015/263630 | DOI Listing |
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