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Somatostatin-expressing neurons in the medial prefrontal cortex promote sevoflurane anesthesia in mice.

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Key Laboratory of Brain Science, Key Laboratory of Anesthesia and Organ Protection of Ministry of Education (In Cultivation), Zunyi Medical University, Zunyi, 563100, Guizhou Province, China.

Background: The medial prefrontal cortex plays a crucial role in regulating consciousness. However, the specific functions of its excitatory and inhibitory networks during anesthesia remain uncertain. Here we explored the hypothesis that somatostatin interneurons in the medial prefrontal cortex enhance the effects of sevoflurane anesthesia by increasing GABA transmission to pyramidal neurons.

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The fine-grained functional organization of the human lateral prefrontal cortex (PFC) remains poorly understood. Previous fMRI studies delineated focal domain-general, or multiple-demand (MD), PFC areas that co-activate during diverse cognitively demanding tasks. While there is some evidence for category-selective (face and scene) patches, in human and non-human primate PFC, these have not been systematically assessed.

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