AI Article Synopsis
- Hypovitaminosis D is prevalent among individuals with acute myocardial infarction in Trieste, Italy, despite high sunlight exposure.
- In a study of 478 patients, 68% were found to be vitamin D deficient, particularly during autumn and winter months.
- Improved vitamin D levels are associated with increased sun exposure, suggesting sunlight could be a low-cost intervention for vitamin D deficiency management.
Article Abstract
Background: Hypovitaminosis D is a vitamin deficiency that has been increasing in developed countries; it was also suggested as an emerging risk factor for developing of atherosclerosis and acute myocardial infarction. The primary source of vitamin D is its cutaneous synthesis under exposure to sunlight. It has been suggested that 30 min of sun exposure twice weekly leads to sufficient vitamin D synthesis. The residents of Trieste (Italy) are well-known for their high exposure to sunlight in all seasons. We aimed to investigate the vitamin D status in subjects with acute myocardial infarction living in this area.
Methods: Vitamin D status was identified in 478 subjects diagnosed with acute myocardial infarction.
Results: The median serum 25-hydroxyvitamin D concentration was 14.5 [7.8 - 22.7] ng/mL. Vitamin D deficiency and insufficiency were present in 324 (68 %) and 107 (22 %) subjects, respectively. Vitamin D deficiency was less frequent among subjects enrolled in the period from July to the end of September (p < 0.001). In a multivariate analysis vitamin D deficiency was predicted by older age (p = 0.02), female gender (p = 0.002), higher body mass index (p = 0.05), autumn/winter sampling (p < 0.001), increased parathyroid hormone (p = 0.03) and alkaline phosphatase (p = 0.003).
Conclusions: We observed very high prevalence of vitamin D deficiency among subjects with myocardial infarction in all seasons of enrollment. However, it was lower in the summer when sun exposure is higher. The exposure to sunlight may be a cost-saving therapeutic strategy for the management of vitamin D deficiency.
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| http://dx.doi.org/10.1024/0300-9831/a000220 | DOI Listing |
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