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Factors Associated With Mortality Among Hospitalized Children With Acute Bacterial Meningitis in a Resource-Limited Setting: A Retrospective Study.
Cureus
November 2024
Department of Internal Medicine, School of Medicine, Ibb University, Ibb, YEM.
Background: Acute bacterial meningitis (ABM) is a significant public health problem in developing countries, including Yemen, especially during warfare. This is because persistent political turmoil impedes ABM prevalence, etiology, and treatment. Here, we investigate the factors associated with mortality among hospitalized children with ABM in a resource-limited setting.
View Article and Find Full Text PDFAortic valve replacement in a bicuspid aortic valve patient followed by reoperation for ascending aorta rupture: a case report.
Front Cardiovasc Med
December 2024
Department of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Bicuspid aortic valve (BAV), the most common congenital cardiac anomaly, predisposes individuals to aortic stenosis and regurgitation due to valve degeneration. Abnormal hemodynamics, arterial wall characteristics, and genetic factors contribute to ascending aorta dilatation, potentially leading to severe complications like aortic dissection. Presently, the most recent guidelines propose that individuals with BAV requiring valve replacement due to valve dysfunction should undergo simultaneous replacement of the ascending aorta when the diameter of aortic dilatation exceeds 4.
View Article and Find Full Text PDFThe role of personality traits and life stress in alcohol use disorder: Insights from NGF gene polymorphisms of Han Chinese population in Taiwan.
Prog Neuropsychopharmacol Biol Psychiatry
December 2024
Department of Psychiatry, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, ROC; Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei, Taiwan, ROC. Electronic address:
Objective: Alcohol use disorder (AUD) is a complex neuropsychiatric condition influenced by genetic and environmental factors. Nerve growth factor (NGF) plays a crucial role in neuronal neuroplasticity and chronic alcohol consumption may alter NGF levels in specific brain regions. The study investigates the associations between NGF gene polymorphisms, susceptibility to AUD, and specific stress and personality characteristics.
View Article and Find Full Text PDFT-cadherin modulates adipogenic differentiation in mesenchymal stem cells: insights into ligand interactions.
Front Cell Dev Biol
December 2024
Faculty of Medicine, Lomonosov Moscow State University, Moscow, Russia.
Introduction: T-cadherin, a non-canonical member of the cadherin superfamily, was initially identified for its involvement in homophilic recognition within the nervous and vascular systems. Apart from its adhesive function, T-cadherin acts as a receptor for two ligands: LDL, contributing to atherogenic processes, and HMW adiponectin, a hormone with well-known cardiovascular protective properties. However, the precise role of T-cadherin in adipose tissue remains elusive.
View Article and Find Full Text PDFDiscovery of myosin light chain kinase gene variant in a patient with tetralogy of Fallot suffering aortic dissection: Implications for pathogenesis and the role of family and population screening.
Int J Cardiol Congenit Heart Dis
December 2024
Department of Cardiovascular Sciences and NIHR Leicester Biomedical Research Centre, University of Leicester, College of Medicine Biological Sciences and Psychology, Glenfield Hospital, Groby Road LE39QP, Leicester, UK.
Background: Thoracic aortic dissection (TAD) is an uncommon complication in patients with Tetralogy of Fallot (TOF). Information concerning risk factors for TAD in patients with TOF is very limited.
Methods: We report a case of Stanford type A TAD in a female patient with previously repaired TOF.
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