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A 58-year-old female smoker diagnosed with myelodysplastic syndrome (MDS) presented with Raynaud's phenomenon and a "scleroderma-like" pattern on nailfold capillaroscopy. The capillaroscopic abnormalities were observed across all fingers, including those without clinical manifestations of onychomycosis. Over a two-year follow-up, there was no evidence of clinical or serological progression toward a connective tissue disease, particularly systemic sclerosis.

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Objectives: To assess short-term barnidipine efficacy and tolerability on Systemic Sclerosis (SSc)-Raynaud's phenomenon (RP).

Methods: We retrospectively evaluated patients with SSc starting barnidipine 10 mg/day. Raynaud's Condition Score (RCS) and mean blood pressure (MBP) were assessed at baseline and 6-month follow-up.

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Livedoid vasculopathy in hemoglobinopathy-associated chronic leg ulcers.

Ann Hematol

December 2024

Division of Hematology, Department of Medicine, UNC Chapel Hill School of Medicine, Chapel Hill, NC, United States of America.

Chronic leg ulceration is a debilitating manifestation of hemoglobinopathies, and best management is uncertain. Livedoid vasculopathy (LV) is a cutaneous non-inflammatory thrombotic vasculopathy treated with anticoagulation that has been identified in hemoglobinopathy-associated chronic leg ulceration. However, most patients with hemoglobinopathy-associated ulcers do not undergo workup for secondary causes, and the prevalence and relevance of LV is unclear.

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Radial cortex transverse distraction help to treat the Raynaud's phenomenon.

Sci Rep

December 2024

Department of Hand Surgery, Department of Orthopedics, Qilu Hospital of Shandong University, #107 Wenhua Xilu, Jinan, China.

Article Synopsis
  • - Raynaud's phenomenon is a condition that causes spasms in blood vessels of the fingers, leading to reduced quality of life and often fails to respond to conventional treatments for over six months.
  • - A study involving six patients who underwent a new procedure called radial cortex transverse distraction showed promising results, with significant improvements in pain, skin color, and healing of finger ulcers.
  • - The follow-up indicated that this surgical method not only healed bone without complications but also effectively addressed symptoms of Raynaud's phenomenon, suggesting it could be a beneficial treatment option.
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