Infection and preterm birth.

Semin Fetal Neonatal Med

UAB Department of Obstetrics & Gynecology, Division of Maternal-Fetal Medicine, Birmingham, AL, USA.

Published: April 2016

AI Article Synopsis

  • Preterm birth is a major factor contributing to health issues and deaths in newborns.
  • The article reviews research connecting infections to preterm birth, emphasizing that while infections are recognized as a significant risk, the specifics regarding different bacteria and viruses are still unclear.
  • Advanced technologies like microbiomics and metabolomics may help identify the germs responsible, and some strategies are in place to lower the rates of preterm birth.

Article Abstract

Preterm birth (PTB) remains a primary cause of neonatal morbidity and mortality. The purpose of this article is to outline the association between infection and PTB. We performed a search of the PubMed database for relevant scientific work published in English from 1995 to July 2015. Whereas there is substantial evidence regarding infection as a strong risk factor for preterm birth, the role of specific bacterial and viral infections is not totally conclusive. Newer high-dimensional biological technologies such as microbiomics and metabolomics offer hope to identify the causative pathogens. In addition, strategies have been developed to reduce PTB.

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Source
http://dx.doi.org/10.1016/j.siny.2015.12.008DOI Listing

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